- A convenient synthesis of (1 H-azol-1-yl)piperidines
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A convenient preparation of 3- and 4-(1H-azol-1-yl)piperidines by arylation of azoles (i.e., pyrazoles, imidazoles, and triazoles) with 3- and 4-bromopyridines and subsequent reduction of the pyridine ring was developed. The method was extended to benzo analogues of the title compounds. Georg Thieme Verlag Stuttgart · New York.
- Shevchuk, Nadiia V.,Liubchak, Kostiantyn,Nazarenko, Kostiantyn G.,Yurchenko, Aleksandr A.,Volochnyuk, Dmitriy M.,Grygorenko, Oleksandr O.,Tolmachev, Andrey A.
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experimental part
p. 2041 - 2048
(2012/08/07)
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- Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
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Provided are certain chemical entities, pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).
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Page/Page column 124
(2010/08/18)
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- CHEMICAL COMPOUNDS
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The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, Het and m are as defined in the description. The compounds of the present invention are modulators, especially antagonists, of the
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Page/Page column 26
(2009/09/05)
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- IMIDAZOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE
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There is provided an imidazole derivative useful as a thrombosis treating agent, which is represented by the formula (I): wherein R represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents
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Page/Page column 29-30
(2010/02/13)
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- Method of treating cancer using FPT inhibitors and antineoplastic agents
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Disclosed is a method of treating cancer in a patient in need of such treatment comprising administering a therapeutically effective amount of an FPT inhibitor and therapeutically effective amounts of one or more antineoplastic agents. Methods of treating non small cell lung cancer, squamous cell cancer of the head and neck, CML, AML, non-Hodgkin's lymphoma and multiple myeloma are disclosed.
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- Farnesyl protein transferase inhibitors
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Disclosed are compounds of the formula: wherein R8represents a cyclic moiety to which is bound an imodazolylalkyl group; R9represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
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