- Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors
-
A series of thiadiazole derivatives has been designed as potential allosteric, substrate competitive inhibitors of the protein kinase JNK. We report on the synthesis, characterization and evaluation of a series of compounds that resulted in the identifica
- De, Surya K.,Chen, Vida,Stebbins, John L.,Chen, Li-Hsing,Cellitti, Jason F.,Machleidt, Thomas,Barile, Elisa,Riel-Mehan, Megan,Dahl, Russell,Yang, Li,Emdadi, Aras,Murphy, Ria,Pellecchia, Maurizio
-
scheme or table
p. 590 - 596
(2010/05/02)
-
- Synthesis and antifungal activities of ω-(5-arylamino-1,3,4-thiadiazol-2-thio)-ω(1H-1,2,4-triazol-1-yl) acetophenones
-
Several ω-(5-arylamino-1,3,4-thiadiazol-2-thiol)-ω-(1H-1,2,4-triazol-1- yl)acetophenones 4a-i have been synthesized. The representative compounds exhibit some antifungal and plant growth regulatory activities. The structures of these compounds have been confirmed by elemental analyses, 1H NMR, IR and MS spectra.
- Chu, Chang-Hu,Hui, Xin-Ping,Xu, Peng-Fei,Zhang, Zi-Yi,Li, Zhi-Chun,Liao, Ren-An
-
p. 2436 - 2438
(2007/10/03)
-