- An Efficient Synthesis of 2-Substituted Benzimidazoles via Photocatalytic Condensation of o-Phenylenediamines and Aldehydes
-
A photocatalytic method has been developed for the efficient synthesis of functionalized benzimidazoles. This protocol involves photocatalytic condensation of o-phenylenediamines with various aldehydes using the Rose Bengal as photocatalyst. The method was found to be general and was successfully employed for accessing pharmaceutically important benzimidazoles by the condensation of aromatic, heteroaromatic and aliphatic aldehydes with o-phenylenediamines, in good-to-excellent yields. Notably, the method was found to be effective for the condensation of less reactive heterocyclic aldehydes with o-phenylenediamines.
- Kovvuri, Jeshma,Nagaraju, Burri,Kamal, Ahmed,Srivastava, Ajay K.
-
-
Read Online
- Role of Pd(II)–chitooligosaccharides–Gboxin analog in oxidative phosphorylation inhibition and energy depletion: Targeting mitochondrial dynamics
-
In this work, we have successfully upgraded the crab wastes into Pd(II) complex of Gboxin analog–chitooligosaccharides conjugate (Pd(II)COS@GbA). This new complex has a high capacity to inhibit the proliferation of prostate cancer cells (IC50?=?1.92?μg/ml). This activity could be attributed to its ability to induce mitochondrial fragmentation through increasing mitochondrial fission dynamin-related protein 1 (p?a selective cytotoxic agent for prostate cancer.
- Elbehairi, Serag Eldin I.,Alfaifi, Mohammad Y.,Shati, Ali A.,Alshehri, Mohammed A.,Elshaarawy, Reda F.M.,Hafez, Hani S.
-
-
Read Online
- An easy one-step photocatalytic synthesis of 1-aryl-2-alkylbenzimidazoles by platinum loaded TiO2 nanoparticles under UV and solar light
-
One-pot synthesis of disubstituted benzimidazoles from N-substituted 2-nitroanilines or 1,2-diamines with 3-12 nm-sized platinum particles loaded on the TiO2 using solar and UV-A light is described. 1-Aryl-2-alkylbenzimidazoles from 2-nitrodiphenylamines are formed by combined redox photocatalytic reaction, condensation and catalytic dehydrogenation on Pt-TiO2. In case of diamines, this reaction is proceeded by Pt-TiO2 assisted photocatalytic oxidation of an alcohol and a catalytic dehydrogenation of the intermediate on the surface of platinum nanoparticles. In both cases product formation was achieved by tandem photocatalytic and catalytic reactions on Pt-TiO2.
- Selvam,Swaminathan
-
experimental part
p. 3386 - 3392
(2011/06/28)
-
- Microwave-assisted one step high-throughput synthesis of benzimidazoles
-
One-pot synthesis of benzimidazoles from diamines and carboxylic acids was developed under microwave irradiation condition, which provided a practical and efficient method for high-throughput synthesis of this important class of heterocyclic compounds.
- Lin, Shou-Yuan,Isome, Yuko,Stewart, Ethan,Liu, Ji-Feng,Yohannes, Daniel,Yu, Libing
-
p. 2883 - 2886
(2007/10/03)
-
- ORGANOLITHIUM AND ORGANOSODIUM COMPOUNDS OF N-SUBSTITUTED 2-ALKYLBENZIMIDAZOLES
-
Organolithium and organosodium compounds of 1,2-dimethyl-, 1-methyl-2-ethyl-,1-methyl-2-propyl-, and 1-phenyl-2-methylbenzimidazole, containing the metal in the alkyl group at position C(2), were obtaind by metallation.It was found that metallation can be complicated by the addition of metalling reagent at the C=N bond of the heterocycle.It was shown that the obtained organometallic compounds can be used for the synthesis of various derivatives of benzimidazole.
- Tertov, B.A.,Bogachev, Yu.G.,Koshchienko, Yu.V.,Suvorova, G.M.,Tsupak, E.B.,et al.
-
p. 868 - 872
(2007/10/02)
-
- Chromic Acid Oxidation of Some Benzimidazole Derivatives
-
Chromic acid oxidation of some benzimidazole derivatives has been carried out.The results indicate that unlike 1,2-disubstituted-4-quinazolinones , in 1,2-disubstituted benzimidazoles the hetero ring double bond does not unde
- Chattopadhyay, Subhagata
-
p. 242 - 243
(2007/10/02)
-