- Synthesis of the selective 5-hydroxytryptamine 4 (5-HT4) receptor agonist (+)-(S)-2-chloro-5-methoxy-4-[5-(2-piperidylmethyl)-1,2,4-oxadiazol- 3-yl]aniline
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In a search for novel 5-hydroxytryptamine 4 (5-HT4) agonists focusing on the linker group of benzamide derivatives, 2-chloro-5-methoxy-4-[5-(2- piperidylmethyl)-1,2,4-oxadiazol-3-yl]aniline (2) was prepared and its optical isomers were separate
- Suzuki, Takeshi,Iwaoka, Kiyoshi,Imanishi, Naoki,Nagakura, Yukinori,Miyata, Keiji,Nakahara, Hideaki,Ohta, Mitsuaki,Mase, Toshiyasu
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p. 120 - 122
(2007/10/03)
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- 5-HT4 receptor antagonists
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The invention provides the use of a compound of formula (I) STR1 wherein A, E, F, U, X, Y, Z, are as defined in the specification, or a pharmaceutically acceptable salt thereof, for the treatment of diarrhea predominant irritable bowel syndrome.
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