cas 14790-42-2, 4-chloro-2-phenylpyrimidine

Articles about 14790-42-2Total 5 be found

Article title
Article abstract
Author
Journal number and time
Download

Deaminative chlorination of aminoheterocycles
Selective modification of heteroatom-containing aromatic structures is in high demand as it permits rapid evaluation of molecular complexity in advanced intermediates. Inspired by the selectivity of deaminases in nature, herein we present a simple methodology that enables the NH2 groups in aminoheterocycles to be conceived as masked modification handles. With the aid of a simple pyrylium reagent and a cheap chloride source, C(sp2)?NH2 can be converted into C(sp2)?Cl bonds. The method is characterized by its wide functional group tolerance and substrate scope, allowing the modification of >20 different classes of heteroaromatic motifs (five- and six-membered heterocycles), bearing numerous sensitive motifs. The facile conversion of NH2 into Cl in a late-stage fashion enables practitioners to apply Sandmeyer- and Vilsmeier-type transforms without the burden of explosive and unsafe diazonium salts, stoichiometric transition metals or highly oxidizing and unselective chlorinating agents. [Figure not available: see fulltext.]
Ghiazza, Clément,Faber, Teresa,Gómez-Palomino, Alejandro,Cornella, Josep
p. 78 - 84
(2021/12/23)

Discovery of wtRET and V804MRET Inhibitors: From Hit to Lead
Oncogenic activation of RET kinase has been found in several neoplastic diseases, like medullary thyroid carcinoma, multiple endocrine neoplasia, papillary thyroid carcinoma, and non-small-cell lung cancer. Currently approved RET inhibitors were not originally designed to be RET inhibitors, and their potency against RET kinase has not been optimized. Hence, novel compounds able to inhibit both wild-type RET (wtRET) and its mutants (e.g., V804MRET) are needed. Herein we present the development and the preliminary evaluation of a new sub-micromolar wtRET/V804MRET inhibitor, N-(2-fluoro-5-trifluoromethylphenyl)-N′-{4′-[(2′′-benzamido)pyridin-4′′-ylamino]phenyl}urea (69), endowed with a 4-anilinopyridine structure, starting from our previously identified 4-anilinopyrimidine hit compound. Profiling against a panel of kinases indicated 69 as a multi cKIT/wtRET/V804MRET inhibitor.
Mologni, Luca,Dalla Via, Martina,Chilin, Adriana,Palumbo, Manlio,Marzaro, Giovanni
p. 1390 - 1398
(2017/09/01)

SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE
The present invention relates to pyridines, pyrimidines and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic beta cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
-
Page/Page column 14

(2010/10/20)

Microwave-assisted, efficient and regioselective Pd-catalyzed C-phenylation of halopyrimidines
We herein report that flash heating microwave irradiation is a helpful tool in the formation of arylpyrimidines from the corresponding halopyrimidines. The palladium-catalyzed cross-coupling reactions of 2,4-di- and 2,4,5-trihalopyrimidines with phenylboronic acid under the above conditions are described. By use of the appropriate catalyst and the adequate halopyrimidine, good regioselectivity can be achieved in the 2-, 4-, or 5-positions of the heterocycle. In addition, we show that this methodology is ameneable for the stepwise preparation of mono-, di-, and triphenylpyrimidines.
Ceide, Susana Conde,Montalban, Antonio Garrido
p. 4415 - 4418
(2007/10/03)

PYRIMIDINES USEFUL AS MODULATORS OF VOLTAGE-GATED ION CHANNELS
The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
-
Page 130-131

(2010/02/10)

Chemical Properties

Melting Point: 73-74℃
Boiling Point: 213.2°Cat760mmHg
Flash Point:102.8°C
Density: 1.245g/cm³
Storage Temp.:Inert atmosphere,Room Temperature
Vapor Pressure: 0.242mmHg at 25°C
PKA: -0.38±0.20(Predicted)
PSA: 25.78000
LogP: 2.79700

Global suppliers and manufacturers of 14790-42-2total 34 suppliers on LookChem

Company Name
Business Type
Min Order
FOB Price
Main Products
Contact

Dayang Chem (Hangzhou) Co.,Ltd.
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:USD $ 3.0-3.0 / Kilogram
Main Products:993
Country:

Zhuozhou Wenxi import and Export Co., Ltd
Business Type:Trading Company
Min Order:1 Kilogram
FOB Price:USD $ 139.0-210.0 / Kilogram
Main Products:1
Country:

SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Business Type:Lab/Research institutions
Min Order:4 Kilogram
FOB Price:No Data
Main Products:35
Country:

Hangzhou J&H Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:46
Country:

Zibo Dorne chemical technology co. LTD
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:No Data
Main Products:69
Country:

Hangzhou Huarong Pharm Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:65
Country:

Hunan chemfish Pharmaceutical co.,Ltd
Business Type:Manufacturers
Min Order:No Data
FOB Price:No Data
Main Products:29
Country:

Shanghai Finebiotech Co.,Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:15
Country:

Kono Chem Co.,Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:86
Country:

Henan Tianfu Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:67
Country:

Hangzhou Fandachem Co.,Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:52
Country:

SAGECHEM LIMITED
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:33
Country:

Hunan Russell Chemicals Technology Co.,Ltd
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:17
Country:

Shenzhen Foris Technology Co. LTD
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:8
Country:

ZHEJIANG JIUZHOU CHEM CO.,LTD
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:26
Country:

Bide Pharmatech Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Amadis Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:10 Milligram
FOB Price:No Data
Main Products:1
Country:

suzhou BetterBioChem Co., Ltd.
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:No Data
Main Products:1
Country:

Chemical Technology Co.,LTD
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Nanjing Zhiyan Pharmaceutical Technology Co. Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 14790-42-2

Article Database

14790-42-2

Articles about 14790-42-2Total 5 be found

More Articles about upstream products of 14790-42-2

More Articles about downstream products of 14790-42-2

Chemical Properties

Melting Point: 73-74℃

Boiling Point: 213.2°Cat760mmHg

Flash Point:102.8°C

Density: 1.245g/cm³

Storage Temp.:Inert atmosphere,Room Temperature

Vapor Pressure: 0.242mmHg at 25°C

PKA: -0.38±0.20(Predicted)

PSA: 25.78000

LogP: 2.79700

Global suppliers and manufacturers of 14790-42-2total 34 suppliers on LookChem

Article Database

14790-42-2

Articles about 14790-42-2Total 5 be found

More Articles about upstream products of 14790-42-2

More Articles about downstream products of 14790-42-2

Chemical Properties

Melting Point: 73-74℃

Boiling Point: 213.2°Cat760mmHg

Flash Point:102.8°C

Density: 1.245g/cm3

Storage Temp.:Inert atmosphere,Room Temperature

Vapor Pressure: 0.242mmHg at 25°C

PKA: -0.38±0.20(Predicted)

PSA: 25.78000

LogP: 2.79700

Global suppliers and manufacturers of 14790-42-2total 34 suppliers on LookChem

Density: 1.245g/cm³