- AN IMPROVED PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
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: Disclosed herein is an improved process for the preparation of Ivabradine and pharmaceutically acceptable salts thereof. The invention more particularly disclosesthe synthesis of key intermediates viz.,(S)-N-[(4,5-dimethoxybenzocydobut-l-yl)-methyl]-N- (methyl)amine hydrochloride of Formula-II and 3-(3-Iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzapin-2-one of Formula-III, and its use in industrial synthesis of Ivabradine and pharmaceutically acceptable salts thereof.
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Page/Page column 19
(2019/11/12)
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- PROCESS FOR MAKING IVABRADINE
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The invention relates to an improved process for making ivabradine of formula (I) or an acid addition salt thereof, by hydrogenation of dehydroivabradine of formula (II) as well as to an improved process for making said dehydroivabradine of formula (II) or an acid addition salt thereof.
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Page/Page column 15; 16
(2014/08/07)
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- PROCESS FOR PREPARATION OF IVABRADINE
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A process for the preparation of ivabradine pharmaceutically acceptable salts is disclosed. An amorphous form of ivabradine hydrochloride and a process for the preparation of it are also provided.
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Paragraph 0121
(2014/07/21)
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- IVABRADINE HYDROCHLORIDE AND THE PROCESSES FOR PREPARATION THEREOF
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The present disclosure relates to a process of preparing Ivabradine Hydrochloride, which is devoid of product related impurities. More specifically, the present disclosure provides a process to obtain a new polymorph of Ivabradine Hydrochloride, wherein said polymorph is pure and devoid of impurities at particular RRTs. The disclosure further relates to the removal of specific impurities of Formula 8 and/or Formula 9 during the preparation of said Ivabradine Hydrochloride. The disclosure also specifically provides the said polymorphic form of Ivabradine Hydrochloride.
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Page/Page column 13
(2014/02/16)
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- PROCESS FOR PREPARATION OF IVABRADINE
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The present invention describes a new process for optical resolution of [N-[[3,4- dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]-N-methylamine] which is an intermediate in the preparation of ivabradine.
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Page/Page column 19-20
(2010/07/09)
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- Parallel solid-phase synthesis of zatebradine analogues as potential If channel blockers
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The first solid-phase synthesis of zatebradine 1 and its analogues is reported. This has resulted in the preparation of compounds with increased ability to reduce the spontaneous beating of isolated guinea-pig atria in a concentration-dependent manner. One example, 8g, showed a maximum reduction of beating of 80% at 3 μM compared to a reduction of 40% at 3 μM with zatebradine 1.
- Bom, Anton,Booth, Susan,Bruin, John,Clark, John,Miller, Susan,Wathey, Bernard
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p. 2351 - 2354
(2007/10/03)
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- (Benzocycloalkyl) alkylamines
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The compounds are 3-[ (benzocycloalkyl)alkyl amino alkyl] -1,3,4,5-te trahydro 2H- 3-benzazepin-2 ones useful in cardiovascular field.A compound disclosed is (R,S)-7,8-dimethoxy-3-{3-{N-[(4,5-dimethoxybenzocyclobut-1-yl) methyl]-N-methyl amino}propyl}-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one.
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