- UREA COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF
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A compound of the formula: [whereinR1 is a hydrocarbon group which may be substituted;R2 is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted;R3 is halogen atoms, a carbam
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- SYNTHESE D'UN ANALOGUE DU FOSTEDIL: LE DIETHYL 4-(1,2,3-DIAZAPHOSPHOL-5-YL)BENZYLPHOSPHONATE. ETUDE DE SON ACTIVITE INHIBITRICE DU TRANSPORT CALCIQUE A TRAVERS LES MEMBRANES BIOLOGIQUES
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We describe a four step synthesis of dicoordinated phosphorus Fostedil analogues: the diethyl-4(1,2,3-diazaphosphol-5-yl)benzylphosphonates 6, in which the benzothiazole Fostedil group is replaced by a 1,2,3 diazaphosphole ring.Inhibitive activity of calcium transfert, through biological membranes, of compounds 6 is weak. Key words: 1,2,3-Diazaphospholes; Fostedil analogues, calcium antagonist.
- Rodi, Youssef Kandri,Lopez, Lucien,Bellan, Jacques,Barrans, Jean,Essassi, El Moktar
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p. 225 - 231
(2007/10/02)
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- Evaluation of inhibitory calcic activity of a series of diethylbenzylphosphonates
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Thirty-nine diethyl benzylphosphonates related to Fostedil were evaluated as calcium antagonists, using the inhibition test on aortic contraction in the rabbit, which was more selective than the negative inotropic activity test on guinea-pig left atrial m
- Tchani,Baziard-Mouysset,Younes,Bellan,Payard,Stigliani,Grassy,Bonnafous,Tisne-Versailles
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p. 845 - 850
(2007/10/02)
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