- COMPOUNDS THAT INHIBIT MCL-1 PROTEIN
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Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (I), or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
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- Carbostyril carboxylic compounds and intermediates, preparation method and application thereof
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The invention discloses carbostyril carboxylic compounds and hydrochlorides thereof and also discloses a preparation method of the compounds and the hydrochlorides thereof as well as an application of the compounds and the hydrochlorides thereof in preparing gram-positive bacterium-preventing or gram-negative bacterium-preventing drugs. Moreover, the invention discloses intermediates for preparing the compounds and a preparation method of the intermediates.
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Paragraph 0146; 0150
(2017/07/12)
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- Enantiomerically pure 2-piperazinemethanols as novel chiral ligands of oxazaborolidine catalysts in enantioselective borane reductions
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Novel enantiomerically pure 2-piperazinemethanols (3-5) were synthesized from 2-piperazinecarboxylic acid 1. The asymmetric reduction of aromatic ketones, ketimine and oxime ether has been performed with reagents prepared from 2-piprazinemethanol and borane to yield enantiomerically enriched alcohols and amines, respectively. The preferred absolute configuration of the product was dependent on the structure of the sulfonyl substituent in the chiral ligand.
- Inoue, Tsutomu,Sato, Daisuke,Komura, Kenichi,Itsuno, Shinichi
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p. 5379 - 5382
(2007/10/03)
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- A potent new class of κ-receptor agonist: 4-Substituted 1-(arylacetyl)- 2-[(dialkylamino)methyl]piperazines
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The synthesis of 4-substituted 1-(arylacetyl)-2- [(alkylamino)methyl]piperazines (10-22, 26, 27, and 30-33) and their activities as κ-opioid receptor agonists are described. This includes a range of 4-acyl and 4-carboalkoxy derivatives with the latter ser
- Naylor,Judd,Lloyd,Scopes,Hayes,Birch
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p. 2075 - 2083
(2007/10/02)
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