- Gemini surfactant synthesis method (by machine translation)
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The invention discloses Gemini surfactant synthesis method, comprises the following steps: (1) bromo methyl or bromo methyl synthesis; (2) synthesis of potassium xanthate; (3) synthesis of intermediate I; (4) synthesis of intermediate II. Prepared by the method of this invention of the Gemini surfactant, the critical micelle concentration and surface tension are relatively small, there is very good application prospect. (by machine translation)
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Paragraph 0021; 0022; 0023
(2017/08/28)
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- Synthesis and antifungal activities of myristic acid analogs
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Myristic acid analogs that are putative inhibitors of N-myristoyl transferase were tested in vitro for activity against yeasts (Saccharomyces cerevisiae, Candida albicans, Cryptococcus neoformans) and filamentous fungi (Aspergillus niger). Several (±)-2-halotetradecanoic acids including (±)-2-bromotetradecanoic acid (14c) exhibited potent activity against C. albicans (MIC = 39 μM), C. neoformans (MIC = 20 μM), S. cerevisiae (MIC = 10 μM), and A. niger (MIC 42 μM) in RPMI 1640 media. Improved synthetic methods have been developed for the synthesis of 12-fluorododecanoic acid (12a) and 12-chlorododecanoic acid (12c). Three novel fatty acids, 12-chloro-4-oxadodecanoic acid (8a), 12-phenoxydodecanoic acid (12i), and 11-(4-iodophenoxy)-undecanoic acid (13d) were also synthesized and tested.
- Parang, Keykavous,Knaus, Edward E.,Wiebe, Leonard I.,Sardari, Soroush,Daneshtalab, Mohsen,Csizmadia, Ferenc
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p. 475 - 482
(2007/10/03)
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