- Stabilizing labeled antibody using amino acids
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The present invention relates to a method for stabilizing a labeled antibody in a solution, in which the labeled antibody is stabilized by allowing the labeled antibody to be present together with at least one of amino acid and a derivative thereof in the solution.
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- Isolation of nucleic acids
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A method for extracting nucleic acids from a biological material such as blood comprises contacting the mixture with a material at a pH such that the material is positively charged and will bind negatively charged nucleic acids and then eluting the nucleic acids at a pH when the said materials possess a neutral or negative charge to release the nucleic acids. The nucleic acids can be removed under mildly alkaline conditions to the maintain integrity of the nucleic acids and to allow retrieval of the nucleic acids in reagents that are immediately compatible with either storage or analytical testing.
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- Isolation of nucleic acids
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A method for extracting nucleic acids from a biological material such as blood comprises contacting the mixture with a material at a pH such that the material is positively charged and will bind negatively charged nucleic acids and then eluting the nucleic acids at a pH when the said materials possess a neutral or negative charge to release the nucleic acids. The nucleic acids can be removed under mildly alkaline conditions to the maintain integrity of the nucleic acids and to allow retrieval of the nucleic acids in reagents that are immediately compatible with either storage or analytical testing.
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- Facile hydrolysis and formation of amide bonds by N-hydroxyethylation of α-amino acids
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The C-terminal amides of α-amino acids are readily hydrolyzed at 25°and pH 7 when the N-terminus is N-hydroxyethylated, with one or two hydroxyethyl The reaction proceeds via cyclization to a morpholinolactone (2) which is rapidly hydrolyzed by water. In the presence of equimolar amounts of amines or amino acid derivatives, 2 reacts in H2O without condensing agents to form a new peptide bond.
- Suggs, J. William,Pires, Richard M.
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p. 2227 - 2230
(2007/10/03)
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- Hydroxyl ions as unique therapeutic agents and compounds that modulate these ions
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The invention concerns the discovery of the surprising and unexpected therapeutic effects of hydroxyl ions. The observed medicinal properties of these ions are both novel and broad in scope. The acute corrosive effects and toxicity of hydroxyl ions on living tissue has previously overwhelmed their therapeutic attributes. Unique hydroxyl ion modulating compounds have been discovered and are within the scope of the invention. When used appropriately as companions with hydroxyl ions, these modulating compounds obviate and attenuate the harmful effects of hydroxyl ions, unmasking and revealing their previously unknown and undemonstratable therapeutic properties. These hydroxyl ion modulating compounds do not significantly interfere with the surprising and unexpected therapeutic benefits of the hydroxyl ions. The novel hydroxyl ion modulating compounds are generally characterized as N,N-disubstituted-aminoacetate salts and substituted N,N-substituted-aminoacetate salts.
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- High-Yield Syntheses of N-(2-Hydroxyethyl)-N-alkylglycine Derivatives by Reaction of Ethanolamines with Glyoxal
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N-(2-hydroxyethyl)-N-alkylglycine derivatives may be conveniently prepared in high yields from N-alkylethanolamines and glyoxal.
- Farfan, Norberto,Cuellar, Laura,Aceves, Juan Manuel,Contreras, Rosalinda
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p. 927 - 929
(2007/10/02)
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- Process for producing hydroxyalkylaminoacetic acids
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Process for producing hydroxyalkylaminoacetic acids having the general formula (I): in which: R represents a hydrogen atom, a C1 -C18 -alkyl group, with straight or ramified chain, or a phenyl group possibly substituted by one or more radicals (preferably one or two) selected from the group comprising: C1 -C4 -alkyl, C1 -C4 -alcoxy or halogeno radicals; R1 represents a hydrogen atom or a C1 -C4 -alkyl group; R2 represents a C1 -C18 -alkyl group or R3 --CHOH--CHR4 --group in which R3 identical to R represents a hydrogen atom or a C1 -C18 -alkyl group with straight or ramified chain, and R4 is identical to R1, according to which glyoxal is reacted hot upon a secondary hydroxylated amine having the general formula (III): STR1 in which R, R1 and R2 have the meaning as given above.
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