- Preparation method of levamlodipine benzenesulfonate (by machine translation)
-
The invention belongs to the technical field of drug synthesis and provides a production method of levamlodipine benzenesulfonate, which comprises the following steps: (R, S)-amlodipine is reacted with a resolving agent. The method is simple and convenient to operate, does not need special equipment, and has a better industrial application prospect. (by machine translation)
- -
-
Paragraph 0095-0097
(2020/07/24)
-
- Combined use of ionic liquid and hydroxypropyl-β-cyclodextrin for the enantioseparation of ten drugs by capillary electrophoresis
-
In the present study, hydroxypropyl-β-cyclodextrin and an ionic liquid (1-ethyl-3-methylimidazolium-l-lactate) were used as additives in capillary electrophoresis for the enantioseparation of 10 analytes, including ofloxacin, propranolol hydrochloride, dioxopromethazine hydrochloride, isoprenaline hydrochloride, chlorpheniramine maleate, liarozole, tropicamide, amlodipine benzenesulfonate, brompheniramine maleate, and homatropine methylbromide. The effects of ionic liquid concentrations, salt effect, cations, and anions of ionic liquids on enantioseparation were investigated and the results proved that there was a synergistic effect between hydroxypropyl-β-cyclodextrin and the ionic liquid, and the cationic part of the ionic liquid played an important role in the increased resolution. With the developed dual system, all the enantiomers of 10 analytes were well separated in resolutions of 5.35, 1.76, 1.85, 2.48, 2.88, 1.43, 5.45, 4.35, 2.76, and 2.98, respectively. In addition, the proposed method was applied to the determination of the enantiomeric purity of S-ofloxacin after validation of the method in terms of selectivity, repeatability, linearity range, accuracy, precision, limit of detection (LOD), and limit of quality (LOQ). Chirality 25:409-414, 2013.
- Cui, Yan,Ma, Xiaowei,Zhao, Min,Jiang, Zhen,Xu, Shuying,Guo, Xingjie
-
p. 409 - 414
(2013/07/26)
-
- A novel chiral resolving reagent, bis((s)-mandelic acid)-3-nitrophthalate, for amlodipine racemate resolution: Scalable synthesis and resolution process
-
A novel bis((S)-mandelic acid)-3-nitrophthalate (1), a chiral resolving reagent for the separation of (S)-(-)-isomers of amlodipine from the racemate thereof, is designed and synthesized. A simple three-step pilot-scale preparation of 1, along with the optimization of a resolution process on the racemate amlodipine, is reported.
- Lee, Hong Woo,Shin, Sung Jae,Yu, Hosung,Kang, Sung Kwon,Yoo, Choong Leol
-
experimental part
p. 1382 - 1386
(2010/04/22)
-
- CRYSTALLINE S-(-)-AMLODIPINE OROTATE ANHYDROUS AND PREPARATION METHOD THEREOF
-
Disclosed are crystalline S- (-) -amlodipine orotate anhydrous and a preparation method thereof. The crystalline S- (-) -amlodipine orotate anhydrous according to the present invention exhibits excellent physical and chemical properties including non-hygroscopicity, solubility, thermal stability, and photostability, and is superior in formulation processability and long-term storage safety.
- -
-
Page/Page column 12
(2008/12/07)
-
- PROCESS FOR PRODUCING ENANTIOMER OF AMLODIPINE IN HIGH OPTICAL PURITY
-
The present invention relates to a process for preparation of optically pure (S)-amlodipine-L-hemitartrate DMF solvate comprising the steps of treating (R,S) amlodipine base with L-tartaric acid in the presence of dimethyl formamide and a co-solvent. The invention also relates to a process for converting (R) or(S)-amlopidine-L-hemitartrate DMF solvate into their besylates without isolating free chiral amlopidine base after solution.
- -
-
Page/Page column 18-19
(2010/11/08)
-
- Process for preparation of chiral amlodipine salts
-
A process for the preparation of pharmaceutically acceptable salts of chiral Amlodipine namely S(?) Amlodipine and R(+) Amlodipine from without isolation of a free base from with optical purity rank between 96-99% is described in the present invention. The process comprises resolving RS amlodipine base using of L(+) or D(?) tartaric acid to obtain salt of corresponding to the acid used in ee rang from 96-99%.
- -
-
Page column 7
(2008/06/13)
-
- A process for the preparation of s (-) amlodipine salts
-
Described herein is a process for the preparation of S(-)Amlodipine salts which comprises reaction of S(-)Amlodipine base with a solution of pharmaceutically acceptable acid such as benzene sulfonic acid, oxalic acid, maleic acid, succinic acid and p-toluene sulfonic acid. The reaction is carried out in the presence of an organic solvent at room temperature. The organic solvents include alcohols like ethanol, methanol, 2-propanol, hydrocarbons like toluene and polar solvents like dimethyl sulfoxide. The salt is obtained by addition of water and isolation of the salt formed by filtration. The unique feature of the invention is production of S(-) Amlodipine besylate in good chemical yield, high enantiomeric purity and with the quality required for preparation of pharmaceutical composition i.e. tablet formulation.
- -
-
Page/Page column 4-5
(2008/06/13)
-