Formyloxy-acetonitrile - A reagent for convenient N- and O-formylations
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Deutsch,Duczek,Niclas
p. 488 - 490
(2007/10/03)
A convenient procedure for the formylation of amines and alcohols using cyanomethyl formate
A simple metyod for the direct formylation of amines using cyanomethyl formate is described. The formylation succeeds in moderate to high yields under mild and neutral conditions. Thus, formamides 2a-f, 2i-m are obtained at room temperature. A chemoselective N-formylation is achieved in the case of ethanolamine. The formylation of nitroanilines and the O-formylation of alcohols only succeeds in the presence of a catalytic amount of imidazole leading to 2g,h and 3a-e, respectively.
Deutsch,Niclas
p. 1561 - 1568
(2007/10/02)
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