cas 150812-13-8, Retigabine Dihydrochloride

Articles about 150812-13-8Total 3 be found

SALTS OR CO-CRYSTALS OF ETHYL N-[2-AMINO-4-[(4-FLUOROPHENYL)METHYLAMINO]-PHENYL]CARBAMATE
A salt or co-crystal of ethyl N-[2-amino-4-[(4-fluorophenyl)methylamino]- phenyl]carbamate and one acid selected from the group consisting of hydrobromic acid, hydrochloric acid, methanesulphonic acid, benzenesulphonic acid, fumaric acid and salicylic aci
-
Page/Page column 17

(2014/03/21)

PROCESS FOR THE PREPARATION OF RETIGABINE OF THE FORMULA I AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
The invention relates to process for the preparation of 2-amino-4-(4- fluorobenzylamino)-l-ethoxycarbonylaminobenzene generically known as Retigabine of the formula (I) and its pharmaceutically acceptable salts e.g. Formula IA, particularly to the modification over the prior art processes-I and II disclosed therein in US5384330. The modifications are depicted in the scheme I and scheme II respectively. Disclosed herein are also the novel processes for the preparation of intermediates of formulae M, N and O of the process-I and of formulae R, S, T of process-II, those are used for preparation of Retigabine of the formula I and its pharmaceutically acceptable salts thereof.
-
(2013/03/26)

DIETHYL 4-(4-FLUOROBENZYLAMINO)-1,2-PHENYLENEDICARBAMATE, AND SALTS THEREOF
Disclosed are diethyl 4-(4-fluorobenzylamino)-l,2-phenylenedicarbamate (IV) and salts thereof, which are useful as reference markers and reference standards for analyzing samples comprising retigabine or salts thereof. Also disclosed is a process for prep
-
Page/Page column 17-18

(2011/02/24)

Chemical Properties

Appearance/Colour :Off-white powder
Melting Point: 168-170°C
Boiling Point: 430 °C at 760 mmHg
Flash Point:213.9 °C
Solubility:≥18.8 mg/mL in DMSO; ≥52.4 mg/mL in H2O with gentle warming; ≥8.71 mg/mL in EtOH with gentle warming and ultrasonic
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Vapor Pressure: 1.34E-07mmHg at 25°C

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.