The substantial improvement of amphotericin b selective toxicity upon modification of mycosamine with bulky substituents
Background: It is assumed that the unfavorable selective toxicity of an antifungal drug Amphotericin B (AmB) can be improved upon chemical modification of the antibiotic molecule. Objective: The aim of this study was verification of the hypothesis that in
Boros-Majewska, Joanna,Borowski, Edward,Chabowska, Izabela,Milewska, Maria J.,Salewska, Natalia,Serocki, Marcin,Milewski, S?awomir,Zi?tkowski, Dominik
p. 128 - 139
(2020/02/04)
N-SUBSTITUTED SECOND GENERATION DERIVATIVES OF ANTIFUNGAL ANTIBIOTIC AMPHOTERICIN B AND METHODS OF THEIR PREPARATION AND APPLICATION
The invention provides semisynthetic N-substituted derivatives of the antifungal antibiotic Amphotericin B and water soluble salts and complexes, pharmaceutical compositions and plant and building treatment products comprising the derivatives and their use as antifungal antibiotics.
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Page/Page column 39
(2014/01/08)
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