2-Substituted tryptamines: Agents with selectivity for 5-HT6 serotonin receptors
Several 2-alkyl-5-methoxytryptamine analogues were designed and prepared as potential 5-HT6 serotonin agonists. It was found that 5-HT6 receptors accommodate small alkyl substituents at the indole 2-position and that the resulting co
Glennon, Richard A.,Lee, Mase,Rangisetty, Jagadeesh B.,Dukat, Malgorzata,Roth, Bryan L.,Savage, Jason E.,McBride, Ace,Rauser, Laura,Hufeisen, Sandy,Lee, David K. H.
p. 1011 - 1018
(2007/10/03)
2-Substituted 5-methoxy-N-acyltryptamines: Synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity
A series of 2-substituted 5-methoxy-N-acyltryptamines was synthesized and their affinity for the melatonin receptor, isolated from whole quail brains, was tested in a succession of in vitro ligand-receptor binding experiments, using 2-[125I]iod