A Short Synthesis of Vicine and Convicine, the Causative Agents of Favism
Vicine (1) and convicine (2) (Vicia faba), causative of the human disease favism, have been conveniently prepared in good yields by a three-step synthesis starting from ethyl glyoxylate.The key step is the reaction of a suitable tetra-O-acetylglucopyranoside with a large excess of guanidine with causes simultaneously deacetylation and coupling. - Key Words: Vicine / Convicine / Favism / Pyrimidines, 5-hydroxy- / Glycosides / Carbohydrates / Trichloroacetimidates
