- Regiospecific 4'-o-β-glucosidation of isoflavones
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The first stereospecific synthesis of isoflavone-4'-O-β-glucosides from unprotected isoflavone aglycones is presented. The procedure, involving a solid/liquid crown ether catalysed phase transfer system has been used for the synthesis of daidzein 4'-O-β-glucoside 3, genistein 4'-O-β-glucoside 4, and of the isoflavone-7-O-β-glucosides genistin and daidzin in improved yields.
- Lewis, Philip T.,Waehaelae, Kristiina
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- Two trifunctional leloir glycosyltransferases as biocatalysts for natural products glycodiversification
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Two promiscuous Bacillus licheniformis glycosyltransferases, YdhE and YojK, exhibited prominent stereospecific but nonregiospecific glycosylation activity of 20 different classes of 59 structurally different natural and non-natural products. Both enzymes transferred various sugars at three nucleophilic groups (OH, NH2, SH) of diverse compounds to produce O-, N-, and S-glycosides. The enzymes also displayed a catalytic reversibility potential for a one-pot transglycosylation, thus bestowing a cost-effective application in biosynthesis of glycodiversified natural products in drug discovery.
- Pandey, Ramesh Prasad,Bashyal, Puspalata,Parajuli, Prakash,Yamaguchi, Tokutaro,Sohng, Jae Kyung
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supporting information
p. 8058 - 8064
(2019/10/14)
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- COMPOUNDS FOR IMMUNOPOTENTIATION
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Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed.
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Page/Page column 115
(2010/02/15)
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