- Preparation method for fluocortolone
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The invention relates to a preparation method for fluocortolone; through a Grignard reaction of a compound represented by the formula I, fluocortolone represented by the formula II is generated. The preparation method for fluocortolone is simple in route and easy to operate, has the raw material easy to obtain, and greatly reduces production costs and industrialized conditions.
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Paragraph 0031; 0032
(2018/03/25)
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- Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
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Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.
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- Novel pregnanoic acid derivatives
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Steroids of the formula SPC1 Wherein X is a hydrogen atom, a halogen atom or methyl; Y is a hydrogen atom or a halogen atom; Z is carbonyl, β-acyloxymethylene or, when Y is a hydrogen atom, also methylene; R1 is a hydrogen atom or methyl; R2 is a hydrogen atom, an alkali metal atom or optionally substituted hydrocarbon; and --A--B-- is --CH=CH--, --CCl=CH-- or when at least one of X, Y and R1 is other than a hydrogen atom, --CH2 --CH2 --, which can be produced by oxidizing a corresponding 20-hydroxy steroid or a corresponding 21-aldehyde, possess topical anti-inflammatory activity.
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