Synthesis and properties of gramicidin S analogs containing D-Phe-L-Pro-D-Val or L-Phe-L-Pro-D-Val sequences in place of D-Phe-L-Pro-L-Val sequence in the β-turn of the antibiotic
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Tamaki,Okitsu,Araki,et al.
p. 531 - 531
(2007/10/02)
FACILE SYNTHESIS OF GRAMICIDIN S VIA CYCLIZATION OF A LINEAR PENTAPEPTIDE
Azide and N-hydroxysuccinimide ester of five pentapeptides related to gramicidin S (cyclic decapeptide) were cyclized to determine the ratio of dimer to monomer in the cyclization product, the pentapeptide dervative with D-Phe as C-terminus giving the dimer in good yield.