- A [...] he [...] synthesis process
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A [...] he [...] synthesis process, in order to (3 R, 4 S) - 3 - hydroxy - 4 - phenyl - 2 - azetidinone as the starting material, adopts the one-pot synthesis, its first with vinyl ether condensation, with the BOC - anhydride is condensed directly [...] h
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Paragraph 0013
(2019/04/06)
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- Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
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The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) STR1 with β-lac
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- Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
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The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) STR1 with β-lac
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- A highly efficient route to taxotere by the β-lactam synthon method
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Taxotere, a highly promising anticancer drug, is synthesized through an efficient coupling of 7,10-diTroc-10-deacetylbaccatin III with enantiomerically pure (3R,4S)-1-tBOC-3-EEO- 4-phenylazetidin-2-one which is obtained via chiral ester enolate - imine cyclocondensation.
- Ojima, Iwao,Sun, Chung Ming,Zucco, Martine,Park, Young Boon,Duclos, Olivier,Kuduk, Scott
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p. 4149 - 4152
(2007/10/02)
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