- Precisely tunable engineering of sub-30 nm monodisperse oligonucleotide nanoparticles
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Advancement of RNAi therapies is mainly hindered by the development of efficient delivery vehicles. The ability to create small size (30 nm) oligonucleotide nanoparticles is essential for many aspects of the delivery process but is often overlooked. In t
- Sizovs, Antons,Song, Xianzhou,Waxham, M. Neal,Jia, Yilong,Feng, Fude,Chen, Jianwei,Wicker, Amanda C.,Xu, Jianming,Yu, Yan,Wang, Jin
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- Heterometallic coordination polymers assembled from trigonal trinuclear Fe2Ni-pivalate blocks and polypyridine spacers: Topological diversity, sorption, and catalytic properties
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Linkage of the trigonal complex [Fe2NiO(Piv)6] (where Piv- = pivalate) by a series of polypyridine ligands, namely, tris(4-pyridyl)triazine (L2), 2,6-bis(3-pyridyl)-4-(4-pyridyl)pyridine (L3), N-(bis-2,2-(4-pyridyloxymethyl)-3-(4-pyridyloxy)propyl))pyridone-4 (L4), and 4-(N,N-diethylamino)phenyl-bis-2,6-(4-pyridyl)pyridine (L5) resulted in the formation of novel coordination polymers [Fe2NiO(Piv)6(L2)]n (2), [Fe2NiO(Piv)6(L3)]n (3), [Fe2NiO(Piv)6(L4)]n·nHPiv (4), and [{Fe2NiO(Piv)6}4{L5}6]n·3nDEF (5, where DEF is N,N-diethylformamide), which were crystallographically characterized. The topological analysis of 3, 4, and 5 disclosed the 3,3,4,4-connected 2D (3, 4) or 3,4,4-connected 1D (5) underlying networks which, upon further simplification, gave rise to the uninodal 3-connected nets with the respective fes (3, 4) or SP 1-periodic net (4,4)(0,2) (5) topologies, driven by the cluster [Fe2Ni(?14;3-O)(?14;-Piv)6] nodes and the polypyridine ?14;3-L3,4 or ?14;2-L5 blocks. The obtained topologies were compared with those identified in other closely related derivatives [Fe2NiO(Piv)6(L1)]n (1) and {Fe2NiO(Piv)6}8{L6}12 (6), where L1 and L6 are tris(4-pyridyl)pyridine and 4-(N,N-dimethylamino)phenyl-bis-2,6-(4-pyridyl)pyridine, respectively. It was shown that a key structure-driven role in defining the dimensionality and topology of the resulting coordination network is played by the type of polypyridine spacer. Compounds 2 and 3 possess a porous structure, as confirmed by the N2 and H2 sorption data at 78 K. Methanol and ethanol sorption by 2 was also studied indicating that the pores filled by these substrates did not induce any structural rearrangement of this sorbent. Additionally, porous coordination polymer 2 was also applied as a heterogeneous catalyst for the condensation of salicylaldehyde or 9-anthracenecarbaldehyde with malononitrile. The best activity of 2 was observed in the case of salicylaldehyde substrate, resulting in up to 88% conversion into 2-imino-2H-chromen-3-carbonitrile.
- Sotnik, Svetlana A.,Polunin, Ruslan A.,Kiskin, Mikhail A.,Kirillov, Alexander M.,Dorofeeva, Victoria N.,Gavrilenko, Konstantin S.,Eremenko, Igor L.,Novotortsev, Vladimir M.,Kolotilov, Sergey V.
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- Synthesis and antibacterial activity of new tetrakisquaternary ammonium compounds based on pentaerythritol and 3-hydroxypyridine
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Tetrakisquaternary ammonium compounds based on pentaerythritol were synthesized for the first time. Bacteriostatic effect of the obtained compounds was evaluated towards opportunistic gram-positive Methicillin-resistant Staphylococcus aureus (strain ATCC
- Vereshchagin,Minaeva,Egorov
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Read Online
- HIGHLY PHOTO-STABLE BIS-TRIAZOLE FLUOROPHORES
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This disclosure is related to photo-stable chromophores which are useful in various applications. Chromophores disclosed herein include a bis-triazole core, two electron-donors at C-4 and C-8, and two groups derived from pentaerythritol (R═OR5)
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Paragraph 0134
(2018/02/28)
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- (S) or (R)-diphenyl-pyrrolidine methanol immobilized by pentaerythritol and its preparation method and application
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The invention discloses a (S/R)-diphenyl-pyrrolidine methanol immobilized by pentaerythritol and its preparation method and application. The (S/R)-diphenyl-pyrrolidine methanol is shown as Formula (I). The preparation of the catalyst includes steps of reacting pentaerythritol with paratoluensulfonyl chloride to obtain pentaerythritol sulphonate; reacting with sodium azide to obtain pentaerythritecompound; reacting (S/R)-N-Cbz-4-hydroxyproline methyl ester with propargyl bromide to obtain (S/R)-N-Cbz-4-acetylene methoxy proline methyl ester; then reacting with chlorophenylmagnesium to obtain (S/R)-diphenyl-pyrrolidine methanol immobilized by pentaerythritol. The (S/R)-diphenyl-pyrrolidine methanol immobilized by pentaerythritol can be applied to the reaction of asymmetrical transformationand generation of prochiral phenyl ketones to be (R/S)- secondary alcohol; the catalyst can be recycled.
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Paragraph 0012
(2018/03/28)
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- [...] compound and its preparation method and application
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The invention discloses a preparation method of 1-(4-(3-(4-(1H-1,2,4-triazole-1-yl)phenoxy)-2,2-bis((4-(1H-1,2,4-triazole-1-yl)phenoxy)methyl)propyloxy)phenyl)-1H-1,2,4-triazole. The preparation method adopts a three-step method comprising an esterification reaction for synthesis of pentaerythritol tetra(p-toluenesulfonate), a replacement reaction for synthesis of 1-bromo-4-(3-(4-bromophenoxy)-2,2-bis((4-bromophenoxy)methyl)propyloxy)benzene, and adopts a one-kettle process for synthesis of 1-(4-(3-(4-(1H-1,2,4-triazole-1-yl)phenoxy)-2,2-bis((4-(1H-1,2,4-triazole-1-yl)phenoxy)methyl)propyloxy)phenyl)-1H-1,2,4-triazole. The preparation method has the characteristics of low production cost and small environmental pollution and is suitable for large-scale industrial production. The monocrystalline compound obtained by the preparation method can be used in the fields of photoelectric materials especially such as dye and luminescence agents.
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Paragraph 0028; 0030
(2017/02/24)
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- Four (4-triazole phenyl) qtr fifth heavenly stem four ether preparation method and application
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A tetra(4-triazolephenyl) pentaerythritol ether single crystal and a preparing method thereof are disclosed. The tetra(4-triazolephenyl) pentaerythritol ether single crystal is prepared by adopting a "one-pot" method, namely by heating p-bromophenyl penta
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Paragraph 0031
(2017/03/14)
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- Selective separation of water, methanol, and ethanol by a porous coordination polymer built with a flexible tetrahedral ligand
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A novel porous coordination polymer, CuII(mtpm)Cl2 [mtpm = tetrakis(m-pyridyloxy methylene)methane], has been synthesized, and its crystal structure has been determined. Its adsorption isotherms for water, methanol, and ethanol are t
- Shigematsu, Akihito,Yamada, Teppei,Kitagawa, Hiroshi
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supporting information; experimental part
p. 13145 - 13147
(2012/09/22)
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- An efficient synthesis of D-galactose-based multivalent neoglycoconjugates
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In this work, the synthesis of dimeric, trimeric and tetrameric D-galactose-based neoglycoconjugates is reported. The monosaccharide ligand was prepared in 5 straightforward steps from D-galactose using the Doebner modification of the Knoevenagel reaction for chain elongation. The ligand was coupled to 1,4-butanediamine, tris-(2-ethylamino)amine, pentaerythrityltetramine and PAMAM dendrimers (1,4-butanodiamine core G0 and 1,12-dodecanediamine core G0). The unprotected glycodendrimers were purified by size-exclusion chromatography (SEC). This was the only step in which a chromatographic method was employed throughout the synthetic route. This is a new and efficient strategy for the preparation of neoglycoconjugates.
- De Andrade, Saulo F.,Figueiredo, Rute C.,De Souza Filho, Jose? D.,Alves, Ricardo J.
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experimental part
p. 1062 - 1069
(2012/09/10)
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- Synthesis and crystal structures of multifunctional tosylates as basis for star-shaped poly(2-ethyl-2-oxazoline)s
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The synthesis of well-defined polymer architectures is of major importance for the development of complex functional materials. In this contribution, we discuss the synthesis of a range of multifunctional star-shaped tosylates as potential initiators for the living cationic ring-opening polymerization (CROP) of 2-oxazolines resulting in star-shaped polymers. The synthesis of the tosylates was performed by esterification of the corresponding alcohols with tosyl chloride. Recrystallization of these tosylate compounds afforded single crystals, and the X-ray crystal structures of di-, tetra-and hexa-tosylates are reported. The use of tetra-and hexatosylates, based on (di)pentaerythritol as initiators for the CROP of 2-ethyl-2-oxazoline, resulted in very slow initiation and illdefined polymers, which is most likely caused by steric hindrance in these initiators. As a consequence, a porphyrin-cored tetratosylate initiator was prepared, which yielded a well-defined star-shaped poly(2-ethyl-2-oxazoline) by CROP as demonstrated by SEC with RI, UV and diode-array detectors, as well as by 1H NMR spectroscopy.
- Hoogenboom, Richard,Fijten, Martin W. M.,Kickelbick, Guido,Schubert, Ulrich S.
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experimental part
p. 773 - 783
(2011/03/19)
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- Alkylated urea and triaminotriazine compounds and phase change inks containing same
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Disclosed are compounds of the formulae wherein Z is a group of the formula —OR1, a group of the formula —SR1, or a group of the formula —NR1R2, Y is a group of the formula —OR3, a group of the formul
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