- Preparation method of 3-substituted dimethyl glutarate and dimethyl glutaconate
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The invention relates to the field of fine chemical engineering, and particularly relates to a preparation method of 3-substituted dimethyl pentodiate and pentene diester. According to the preparationmethod of 3-substituted dimethyl pentodiate and pentene diester, malonic ester and halomethane are used as raw materials, substitution reaction is performed under an alkaline action, then decarboxylation and esterification reaction are performed so as to prepare 3-substituted dimethyl pentodiate or pentene diester, a structural formula of 3-substituted dimethyl pentodiate is as shown in a compound (V), and a structural formula of pentene diester is as shown in a compound (IX). The preparation method of 3-substituted dimethyl pentodiate and pentene diester is mild in reaction conditions, is easy to operate and is safe. The formula is shown in the description.
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Paragraph 0028-0030
(2018/09/08)
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- Asymmetric Synthesis of Optically Active 3-Substituted δ-Valerolactones Using Lipase in Organic Solvents
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In organic solvents, lipase Amano P catalyzed the asymmetric ring opening of glutaric anhydrides bearing -CH2Cl, -CH2F and -OCH3 groups at position 3 with methanol and 1-butanol to afford the corresponding mono esters in 70-86percent e.e.Optically active δ-valerolactones were synthesized from the mono esters in overall yields of 34-62percent.The R-configuration was assigned to the mono esters and the lactones by means of a CD analysis and chemical correlation.This indicates that the lipase preferentially attecked the pro-R carbonyl group of these anhydrides carrying hetero atoms, in keeping with the trend observed for glutaric anhydrides having simple alkyl substituents.
- Yamamoto, Yukio,Iwasa, Mineyuki,Sawada, Seiji,Oda, Jun'ichi
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p. 3269 - 3274
(2007/10/02)
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