Novel synthesis of physovenine and physostigmine analogs
This Letter describes a versatile synthetic approach to prepare physovenine and physostigmine analogs. A series of analogs were synthesized and evaluated for cholinesterase inhibition activities, including human acetylcholinesterase (AChE) and butyrylchol
Cross-metathesis between α-methylene-γ-butyrolactone and olefins: A dramatic additive effect
Olefin cross-metathesis between α-methylene-γ-butyrolactone and terminal olefins is described. Moderate to excellent yields of α-alkylidene-γ-butyrolactones were obtained with high E-stereoselectivity in the presence of low catalyst loading in refluxing CH 2Cl2. In addition, the use of various additives was found to have a dramatic effect on the efficiency of the cross-metathesis (CM) process by circumventing the formation of the isomerized byproduct.
Moise, Joelle,Arseniyadis, Stellios,Cossy, Janine
p. 1695 - 1698
(2008/02/02)
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