- SAR156497, an exquisitely selective inhibitor of Aurora kinases
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The Aurora family of serine/threonine kinases is essential for mitosis. Their crucial role in cell cycle regulation and aberrant expression in a broad range of malignancies have been demonstrated and have prompted intensive search for small molecule Auror
- Carry, Jean-Christophe,Clerc, Fran?ois,Minoux, Hervé,Schio, Laurent,Mauger, Jacques,Nair, Anil,Parmantier, Eric,Le Moigne, Ronan,Delorme, Cécile,Nicolas, Jean-Paul,Krick, Alain,Abécassis, Pierre-Yves,Crocq-Stuerga, Véronique,Pouzieux, Stéphanie,Delarbre, Laure,Maignan, Sébastien,Bertrand, Thomas,Bjergarde, Kirsten,Ma, Nina,Lachaud, Sylvette,Guizani, Houlfa,Lebel, Rémi,Doerflinger, Gilles,Monget, Sylvie,Perron, Sébastien,Gasse, Francis,Angouillant-Boniface, Odile,Filoche-Rommé, Bruno,Murer, Michel,Gontier, Sylvie,Prévost, Céline,Monteiro, Marie-Line,Combeau, Cécile
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Read Online
- New fluorinated 1,2-diaminoarenes, quinoxalines, 2,1,3-arenothia(selena) diazoles and related compounds
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5,6,7,8-Tetrafluoroquinoxaline (1) and its previously unknown derivatives (2-8) were synthesized from glyoxal and polyfluorinated 1,2-diaminoarenes (10-17) obtained by reduction of corresponding 2,1,3-arenothiadiazoles (including new ones 21 and 22). The
- Makarov, Arkady G.,Selikhova, Natalia Yu.,Makarov, Alexander Yu.,Malkov, Victor S.,Bagryanskaya, Irina Yu.,Gatilov, Yuri V.,Knyazev, Alexey S.,Slizhov, Yuri G.,Zibarev, Andrey V.
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p. 123 - 131
(2014/08/18)
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- Synthesis of novel histamine H4 receptor antagonists
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This letter describes the discovery and synthesis of a series of octahydropyrrolo[3,4-c]pyrrole based selective histamine hH4 receptor antagonists. The amidine compound 20 was found to be a potent and selective histamine H4 receptor antagonist with moderate clearance and a high volume of distribution.
- Lane, Charlotte A.L.,Hay, Duncan,Mowbray, Charles E.,Paradowski, Michael,Selby, Matthew D.,Swain, Nigel A.,Williams, David H.
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scheme or table
p. 1156 - 1159
(2012/03/11)
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