A New Synthesis of FPL 64176 and Analogues: The Discovery of Benzoylpyrrole Calcium Channel Activators with Low Nanomolar Potency
Heavy metal assisted halogen displacement on 2-halobenzoylpyrroles (2 and 3) leads to a simple synthesis of FPL 64176 (1) and a variety of analogues (4-10).The difluoro derivative (4), EC 50 1nM, and the amino linked analogue (7), EC 50 2.7nm, are present