- Chlorination of aniline and methyl carbanilate by N-chlorosuccinimide and synthesis of 1,3,5-trichlorobenzene
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Aniline undergoes regioselective trichlorination by N-chlorosuccinimide (NCS) in acetonitrile in good yield. The product 2,4,6-trichoroaniline was converted into 1,3,5-trichlorobenzene by reduction of its diazonium salt. Reaction of the methyl carbamate of aniline with NCS gave only the 2,4-dichlorophenyl carbamate. Copyright Taylor & Francis Group, LLC.
- Davis, Matthew C.
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experimental part
p. 1100 - 1108
(2009/09/08)
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- Synthesis and thiolation of 1,3-difluoro-2,4,6-trihaloanilines and benzenes
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Three pentahaloanilines were prepared by stepwise halogenation of 3,5-difluoroaniline and were deaminated to form pentahalobenzenes. Alternatively, two pentahalobenzenes were obtained by lithiation followed by iodination of 1,3-difluoro-4,6-dihalobenzenes
- Manka, Jason T.,Kaszynski, Piotr
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