- Iodine-mediated one-pot synthesis of C-3 acylated indolizines from pyridines, aryl methyl ketones and acrylate derivatives
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An I2/CuI-promoted multi-component reaction from pyridines, aryl methyl ketones and electron deficient acrylates has been accomplished in a “one-pot” manner, which provides a straightforward and efficient access to C-3 acylated indolizines. The
- Fang, Youlai,He, Lisheng,Pan, Weidong,Yang, Yuzhu
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supporting information
p. 3767 - 3771
(2019/06/08)
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- Preparation method of C-3 arylformylindolizine compounds
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The invention discloses a preparation method of C-3 arylformylindolizine compounds. The method comprises the following steps: adding a metal additive, elemental iodine, a pyridine derivative, aromaticethanone, an electron deficient olefin and a base into
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Paragraph 0030-0033; 0036; 0039; 0061-0065
(2019/09/16)
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- One-pot synthesis of indolizine via 1,3-dipolar cycloaddition using a sub-equivalent amount of K2Cr2O7 as an efficient oxidant under base free conditions
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A one-pot method for synthesizing multi-substituted indolizines from α-halo-carbonyl compounds, pyridines and electron deficient alkenes was developed. A sub-equivalent amount of potassium dichromate was used as an oxidant under base free conditions. The transformation developed should be of economic efficiency.
- Wang, Chao,Hu, Huayou,Xu, Juanfang,Kan, Weiqiu
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p. 41255 - 41258
(2015/05/20)
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- Electrophilicities of 1,2-disubstituted ethylenes
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The kinetics of the reactions of maleic anhydride, N-methylmaleimide, fumaronitrile, diethyl fumarate, and diethyl maleate with pyridinium and sulfonium ylides were studied in DMSO at 20 C. All of the reactions were found to follow a second-order rate law
- Allgaeuer, Dominik S.,Mayr, Herbert
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supporting information
p. 2956 - 2963
(2014/05/20)
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- Iodine-promoted synthesis of acylindolizine derivatives from acetylenecarboxylates and pyridinium, isoquinolinium, or quinolinium ylides
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An iodine-promoted synthesis of acylindolizinecarboxylates via 1,3-dipolar cycloaddition of nitrogen ylides with acetylenecarboxylates and subsequent aromatization for the generation of a wide range of structurally interesting, pharmacologically and photoelectrically significant compounds is reported. Only readily available materials, mild conditions, and operationally trivial reaction protocols were required. Graphical abstract: [Figure not available: see fulltext.]
- Liu, Juanjuan,Yan, Peiyun,Li, Yan,Zhou, Zhengquan,Ye, Weijian,Yao, Juan,Wang, Cunde
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p. 617 - 625
(2014/04/03)
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- Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: Antibacterial and antifungal evaluation of the products
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A number of indolizines and pyrrolo[1,2-a]quinolines/isoquinolines were prepared from phenacyl pyridinium, quinolinium and isoquinolinium salts derived fromthe reaction of the heterocycles with 2-bromo acetophenone with alkynes and alkenes using amberlite-IRA-402 (OH) ion exchange resin as the base. Antibacterial and antifungal studies were carried out against thirteen bacterial and four fungal strains, which revealed that three derivatives (4a, 4b, 7a) out of fifteen are effective against all the thirteen strains and one derivative, 10, showed dual antibactericidal and antifungal efficacy.
- Hazra, Abhijit,Mondal, Shyamal,Maity, Arindam,Naskar, Subhendu,Saha, Pritam,Paira, Rupankar,Sahu, Krishnendu B.,Paira, Priyankar,Ghosh, Soma,Sinha, Chandrima,Samanta, Amalesh,Banerjee, Sukdeb,Mondal, Nirup B.
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experimental part
p. 2132 - 2140
(2011/06/21)
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- Palladium-catalyzed oxidative C-H bond and C=C double bond cleavage: C-3 acylation of indolizines with α,β-unsaturated carboxylic acids
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A novel palladium-catalyzed C-3 acylation of indolizines with α,β-unsaturated carboxylic acids via C-H bond and C=C double bond cleavage under oxidative conditions is described. The regioselectivity is assisted by the carboxylic group, and the selection of the oxidant is crucial to the reaction.
- Yang, Yuzhu,Chen, Li,Zhang, Zhaoguo,Zhang, Yuhong
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supporting information; experimental part
p. 1342 - 1345
(2011/05/08)
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- A Facile Obe-step Synthesis of Aromatic Indolizines by 1,3-Dipolar Cycloaddition of Pyridinium and Related Heteroaromatic Ylides with Akenes in the Presence of TPCD
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A facile and general one-step method is presented for the synthesis of aromatic indolizine compounds 3a-n in moderate to high yields (53-99percent) by reaction of the pyridinium N-ylides 1a-e, the quinolinium N-ylide 11f and the isoquinolinium N-ylide 1g
- Wei, Xudong,Hu, Yuefei,Li, Tingsheng,Hu, Hongwen
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p. 2487 - 2490
(2007/10/02)
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