- 2,6-diisopropyl benzene boric acid derivatives an pharmaceutical use thereof
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The invention relates to a type of 2,6-diisopropyl benzene boric acid derivatives and pharmaceutical use thereof. The structure of the derivatives is accordant with a general formula shown in the description, wherein R1 represents -H or -CH(CH3)2. The drugs are sensitive to free radicals, and a large number of free radicals exist at ischemic parts, so that the drugs are capable of releasing diprivan or analogs of diprivan at the ischemic parts, are capable of well protecting ischemic injury and have a neuroprotective effect better than that of diprivan. The derivatives can be applied to the preparation of drugs for treating the ischemic injury.
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Paragraph 0020; 0021; 0022
(2018/12/02)
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- Suzuki cross-coupling reaction of sterically hindered aryl boronates with 3-iodo-4-methoxybenzoic acid methylester
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The cross-coupling reaction of 3-iodo-4-methoxybenzoic acid methylester with sterically hindered arylboronic esters and especially 5,5-dimethyl-2-mesityl-1,3,2-dioxaborinane, is reported. The optimisation of the process in order to obtain biaryls in good yield by using anhydrous benzene at reflux and sodium phenoxide in the presence of 0.06 equiv. of Pd(PPh3)4 is described. (C) 2000 Elsevier Science Ltd.
- Chaumeil,Signorella,Le Drian
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p. 9655 - 9662
(2007/10/03)
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