- Design, Synthesis, and Biological Evaluation of Novel Pyrazole, Oxazole, and Pyridine Derivatives as Potential Anticancer Agents Using Mixed Chalcone
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New pyrazole, oxazole, and pyridine derivatives bearing naphthalene and furan moieties have been prepared by condensing 3-(furan-2-yl)-1-(naphthalen-2-yl)prop-2-en-1-one 1 with different nitrogen and carbon nucleophiles such as hydrazine, hydroxylamine, c
- Ahmed, Marwa H.,El-Hashash, Maher A.,Marzouk, Magda I.,El-Naggar, Abeer M.
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- Synthesis, Biological Activity and Action Mechanism Study of Novel Chalcone Derivatives Containing Malonate
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A series of novel chalcone malonate derivatives were synthesized and their antibacterial and antiviral activities were evaluated. All target compounds were characterized by spectral data. The results of antimicrobial bioassay showed that one compound (die
- Guo, Tao,Xia, Rongjiao,Liu, Tingting,Peng, Feng,Tang, Xuemei,Zhou, Qing,Luo, Hui,Xue, Wei
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- Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones
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Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are collectively known as chalcones. The cytotoxic potential of chalcones which consists of C6-C 3-C6 units gets enhanced by the incorporation of pyrazole ring as proved by our earlier studies. Thus in the present work, pyrazoles of chalcones with ring A substituted by furan, naphthalene and variety of substituted phenyl rings has been prepared and evaluated for in vitro cytotoxic activity against PC-3, OVCAR, IMR-32, HEP-2 human cancer cell lines. Springer Science+Business Media, LLC 2011.
- Nepali, Kunal,Kadian, Kanika,Ojha, Ritu,Dhiman, Rajni,Garg, Atul,Singh, Gagandip,Buddhiraja, Abhishek,Bedi, Preet Mohinder Singh,Dhar, Kanaya Lal
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p. 2990 - 2997
(2012/10/29)
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- The treatment of pests using certain ethylenically-unsaturated carbonyl compounds
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A pesticidal composition comprising an inert carrier and, as active ingredient, an αβ-unsaturated carbonyl compound selected from:(i) compounds of the formula I wherein R1 is a phenyl group optionally substituted with 1 or 2 chlorine atoms, a naphthyl group or a furyl group optionally substituted by 1 or 2 methyl groups, R2 is a group selected from phenyl, furyl, thienyl, furfuryl, thien-2-ylmethyl or a group of the formula(vi) 2-cyclohexenone; and(vii) 5-phenyl-3-formyl-pyran-4-one. The composition has use particularly in the treatment of pests such as insects and acarids. The invention also provides compounds of formula I above whereinR1 is 2-naphthyl and R2 is furfuryl; orR1 is phenyl and R2 is fur-3-yl; orR2 is fur-3-yl and R1 is 2,5-dimethylfur-3-yl; orR1 is phenyl and R2 is 3,4-methylenedioxyphenyl.
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