Preparation and palladium-catalysed arylation of indolylzinc halides
Indolylzinc halides are prepared by two methods: transmetallation of indolyllithiums with zinc chloride and oxidative addition of active zinc to iodoindoles. The palladium-catalysed reaction of the indolylzinc halides provides a practical method for synthesizing arylindoles.
Indolylzinc iodides by oxidative addition of active zinc to iodoindoles
Indolylzinc derivatives were prepared by the oxidative addition of active zinc to iodoindoles, which coupled with aromatic halides in the presence of palladium catalyst to give arylated indoles.