A convenient and efficient method for the synthesis of 2-hydroxy glycals
A convenient and efficient method for preparing 2-hydroxy glycals was developed from thioglycosides by using 1,4-dioxane-bromine complex/DMAP as an efficient promoter with good yield (61-85%). In this synthetic method, a wide range of sugar thioglycosides could be used as substrates.
PHP-Tethered N-Acyl Carbamate: A Photocage for Nicotinamide
The synthesis of a new photocaged nicotinamide having an N-acyl carbamate linker and a p-hydroxyphenacyl (pHP) chromophore is described. The photophysical and photochemical studies showed an absorption maximum at λ = 330 nm and a quantum yield for release of 11% that are dependent upon both pH and solvent. While the acyl carbamate releases nicotinamide efficiently, a simpler amide linker was inert to photocleavage. This photocaged nicotinamide has significant advantages with respect to quantum yield, absorbance wavelength, rate of release, and solubility that make it the first practical example of a photocaged amide.
Salahi, Farbod,Purohit, Vatsal,Ferraudi, Guillermo,Stauffacher, Cynthia,Wiest, Olaf,Helquist, Paul
supporting information
p. 2547 - 2550
(2018/05/22)
Dioxane dibromide mediated bromination of substituted coumarins under solvent-free conditions
An efficient solvent-free protocol for regioselective bromination of substituted coumarins has been developed by using dioxane dibromide as the solid brominating agent. The efficacy of the solvent-free protocol has been established. The effects of the electronic nature and location of the substituents on the outcome of the reaction have been rationalized with a proposed mechanism.
PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-AMINO-1-PHENYLETHANOLS
Optically active 2-amino-l-phenylethanols of formula (I) or its mirror image, wherein R1 is hydrogen, C1-6alkyl or aryl-substituted C1-6alkyl and R2 through R6 are independently hydrogen, hydroxy or C1-6alkoxy, or salts thereof are prepared by asymmetric hydrogenation of the corresponding 2-aminoacetophenones in the presence of a ruthenium complex catalyst comprising a chiral phosphine ligand.
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Page/Page column 9
(2008/12/06)
PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-AMINO-1-PHENYLETHANOLS
Optically active 2-amino-l-phenylethanols of formula (I) or its mirror image, wherein R1 is C1-6 alkyl or aryl-substituted C1-6 alkyl and R2 through R6 are independently hydrogen, hydroxy or C1-6 alkoxy, or salts thereof are prepared by asymmetric hydrogenation of the corresponding 2-aminoaceto-phenones in the presence of a rhodium complex catalyst comprising a chiral diphosphine ligand, wherein each phosphorus atom is part of a heterocyclic ring system which contains at least one chiral carbon atom directly bound to the phosphorus atom.
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Page/Page column 10-11
(2008/12/08)
Microwave-induced selective synthesis of α-bromo and α,α-dibromoalkanones using dioxane-dibromide and silica gel under solvent-free conditions
Selective synthesis of α-bromo and α,α-dibromoalkanones using dioxane-dibromide and silica gel in solvent-free conditions under microwave irradiation has been reported. The amount of dioxane-dibromide, silica gel and time of irradiation are keys for the selective synthesis of α-bromo and α,α-dibromoalkanones.
Paul, Satya,Gupta, Varinder,Gupta, Rajive,Loupy, André
p. 439 - 442
(2007/10/03)
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