- CHEMOKINE RECEPTOR BINDING COMPOUNDS
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The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR4 or CCR5. In one aspect, these compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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Page/Page column 61
(2010/11/26)
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- The structural proliferation of 2,6-difluoropyridine through organometallic intermediates
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Contrary to a literature claim, 2,6-difluoropyridine-3-carboxaldehyde can be readily prepared by consecutive treatment of 2,6-difluoropyridine with lithium diisopropylamide and N,N-dimethylformamide. Regioselective displacements of fluorine from the aldehyde by nucleophiles were carried out. To demonstrate the versatility of the organometallic approach, some two dozens of further 2,6-difluoropyridine derivatives were prepared applying a combination of modern organometallic methods such as site selective hydrogen/metal and halogen/metal permutations and deprotonation-triggered heavy halogen migrations. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
- Schlosser, Manfred,Rausis, Thierry
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p. 1018 - 1024
(2007/10/03)
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- Synthesis of some piperazinylpyrazolo[3,4-b]pyridines as selective serotonin re-uptake inhibitors
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A number of 3-substituted 6-piperazinylpyrazolo[3,4-b]pyridines were synthesized from 2,6-difluoropyridine by directed ortho metallation and sequential intra- and intermolecular displacement of fluorine. Three derivatives with a cyano group in the 3-position showed activity as selective serotonin re-uptake inhibitors.
- Shutske, Gregory M.,Roehr, Joachim E.
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p. 789 - 795
(2007/10/03)
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