- A convenient synthesis of cyclopropane malonyl peroxide
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Cyclopropane-1,1-dicarbonyl peroxide was prepared in 85% yield by the reaction of diethyl cyclopropane-1,1-dicarboxylate with the urea hydrogen peroxide clathrate in the presence of methanesulfonic acid.
- Terent'Ev, Alexander O.,Vil', Vera A.,Mulina, Olga M.,Pivnitsky, Kazimir K.,Nikishin, Gennady I.
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Read Online
- Polymers Containing Ring-Strain Energy. 1. New Monomers and Polymers Based on Cyclopropane, Norbornadiene, and Quadricyclane
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The synthesis and polymerization chemistry of 1,1-bis(XCH2)cyclopropane was studied.Treatment of 1 with base in the presence of α,ω-dihalides did not produce a polyether.However, treatment of 4 with the bis(alkoxide) derived from hexanediol afforded a polyether of low molecular weight n=3000, PD=3>.A general method for alkylating norbornadiene in the 2-position was developed.Treatment of norbornadiene with tert-BuOK, tetramethylethylenediamine (TMEDA), n-BuLi, and tributylchlorostannane (in that order) afforded 2-(tributylstannyl)norbornadiene in excellent yield.On the other hand, carbon electrophiles required the generation of the 2-(lithiocyanocuprate) in order to effect clean alkylation.Treatment of 2-norbornadiene (8a) with RMgX in the presence of (dppp)NiCl2 afforded the cross-coupling products 2-(XCH2)-norbornadiene in high yield.Polymerization of 9 in THF initiated by n-BuLi resulted in an elastomeric polymer (12) n=18,000, PD=1.5>.Photolysis of 12 in the presence of (Ph3P)2CuBr converted the pendant norbornadiene to quadricyclane (13).Heating of the photoisomerized sample to 180 deg C caused an exothermic (by DSC) reaction which corresponded to 59percent of theory (using the value 26 kcal/mol: quadricyclane -> norbornadiene).
- Wright, Michael E.,Allred, Gary D.,Wardle, Robert B.,Cannizzo, Louis F.
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Read Online
- Synthesis, crystal structure and bioactivity of N-(5-propyl-1,3,4- thiadiazol-2-yl)cyclopropanecarboxamide
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A new 1,3,4-thiadiazole compound with m.f. C9H 13N3OS, has been synthesized and confirmed by 1H NMR and HRMS. The single crystal structure of the 1,3,4-thiadiazole compound was determined by a single crystal X-ray diffraction study. The crystal belongs to the triclinic system, space group P-1 with a = 10.238(2), b = 10.325(2), c = 10.560(2) ?, α = 104.09(3), β = 109.50(3), γ = 93.40(3)°, Z = 4, V = 1008.4(3)?3, Mr = 211.28, Dc = 1.392 g/cm3, S = 0.98, μ = 0.29 mm-1, F(000) = 448, the final R1 = 0.0970 and wR2 = 0.2147 for 1776 were observed with I > 2Σ(I). X-ray indicated that two intermolecular hydrogen bonds N1-H1···N5, N4-H4···N2 were observed. The preliminary biological test shown that the synthesized compound has moderate herbicidal activity against Brassica campestris.
- Sun, Na-Bo,Jin, Jian-Zhong,Lei, Chao,He, Fang-Yue
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Read Online
- 1, 1-cyclopropane dicarboxylic acid amide compound as well as preparation method and application thereof
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The invention discloses a 1, 1-cyclopropane dicarboxylic acid amide compound as well as a preparation method and application thereof, and the structural formula of the 1, 1-cyclopropane dicarboxylic acid amide compound is as shown in a formula (I): in the formula (I), the structures of two substituted benzene rings are the same, the number of substituents R on each substituted benzene ring is 1-3,and the substituent R is selected from H, halogen, C1-C4 alkyl, C2-C4 ester group or C1-C3 alkoxy. The 1, 1-cyclopropane dicarboxylic acid amide compound provided by the invention is a novel compoundwith an efficient weeding effect, and provides a basis for research and development of novel herbicides.
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Paragraph 0024; 0028-0030
(2021/01/11)
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- A 4, 7 - diaza spiro [2.5] octane -7 - formic acid tert-butyl synthetic method
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The invention belongs to the technical field of chemical synthesis of N-heterocycle-containing drug intermediates, and particularly relates to a synthesis method of tert-butyl 4,7-diazaspiro[2.5]octyl-7-formate. By using diethyl malonate as a raw material, cyclization reaction, Hofmann reaction, hydrolysis reaction, acylation reaction for recyclization, reduction reaction and the like are performed to conveniently synthesize the target compound product. The method has the advantages of simple synthesis technique, cheap and accessible raw materials, mild reaction conditions, high controllability, low cost and high yield, and is convenient to operate.
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Paragraph 0036; 0051; 0053; 0054
(2019/01/08)
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- Efficient cyclopropanation of aryl/heteroaryl acetates and acetonitriles with vinyl diphenyl sulfonium triflate
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A convenient method was developed for the cyclopropanation of aryl acetates and aryl acetonitrile using vinyl diphenyl sulfonium triflate salt. The newly developed conditions are simple, mild, and compatible with a wide range of functional groups, without the need to apply an inert atmosphere, or alkali bases.
- Zhou, Mingwei,Hu, Yimin,En, Ke,Tan, Xuefei,Shen, Hong C.,Qian, Xuhong
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supporting information
p. 1443 - 1445
(2018/03/12)
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- Preparation method of compound
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The invention discloses a preparation method of a compound shown in the formula (I). The method is characterized by including the following steps of firstly, mixing the compound shown in the formula (I), a compound shown in the formula (III), strong alkali and weak acid salt and a catalyst to obtain a mixed solution; secondly, conducting heating and refluxing on the mixed solution obtained in the first step, and conducting post-processing to obtain the compound shown in the formula (I), wherein X is Cl, Br or I. The method can effectively improve the yield and safety of the compound shown in the formula (I). Please see the formula in the description.
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Paragraph 0055; 0056; 0057; 0058; 0059; 0060; 0061-0063
(2017/06/27)
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- Preparing method for 1,1-cyclopropyl dimethyl carbinol
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The invention belongs to the technical field of drug synthesis and relates to a preparing method for 1,1-cyclopropyl dimethyl carbinol. Specifically, the preparing method for the 1,1-cyclopropyl dimethyl carbinol includes the following steps that firstly, under the participation of a catalyst A, a solvent A and an acid-binding agent, diethyl malonate and 1,2-dichloroethane are used for preparing 1,1-cyclopropyl dioctyl phthalate diethyl ester; and secondly, under the participation of a solvent B and a catalyst B, a reducing agent is used for reducing the 1,1-cyclopropyl dioctyl phthalate diethyl ester, and the target product 1,1-cyclopropyl dimethyl carbinol is obtained. Raw materials adopted in the preparing method are cheap, easy to obtain and free of toxins, the activity of the catalysts are high, the solvents can be recycled, and the cost is obviously reduced; and reaction conditions are moderate, the products are easy to separate, the three industrial wastes are little, and the environment-friendly chemical requirement is met. In addition, according to the preparing method, the yield of the target product can be obviously increased, and the total recovery can reach 88% through the two steps.
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Paragraph 0039; 0044; 0047; 0050; 0053
(2017/08/28)
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- PYRROLOTRIAZINE INHIBITORS OF IRAK4 ACTIVITY
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The present invention relates to pyrrolotriazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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Page/Page column 50; 51
(2016/09/26)
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- THIENOPYRAZINE INHIBITORS OF IRAK4 ACTIVITY
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The present invention relates to thienopyrazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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Page/Page column 40
(2016/09/26)
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- Discovery of potent c-MET inhibitors with new scaffold having different quinazoline, pyridine and tetrahydro-pyridothienopyrimidine headgroups
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Cellular mesenchymal-epithelial transition factor (c-MET) is closely linked to human malignancies, which makes it an important target for treatment of cancer. In this study, a series of 3-methoxy-N-phenylbenzamide derivatives, N-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl) benzamide derivatives and N1-(3-fluoro-4-methoxyphenyl)-N3-(4-fluorophenyl) malonamide derivatives were designed and synthesized, some of them were identified as c-MET inhibitors. Among these compounds with new scaffolds having different quinazoline, pyridine and tetrahydro-pyridothienopyrimidine head groups, compound 11c, 11i, 13b, 13h exhibited both potent inhibitory activities against c-MET and high anticancer activity against tested cancer cell lines in vitro. In addition, kinase selectivity assay further demonstrated that both 13b and 13h are potent and selective c-MET inhibitors. Molecular docking supported that they bound well to c-MET and VEGFR2, which demonstrates that they are potential c-MET RTK inhibitors for cancer therapy.
- Jiang, Yingnan,Zhang, Ke,Gao, Suyu,Wang, Guihua,Huang, Jian,Wang, Jinhui,Chen, Lixia
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- AMINO ESTER DERIVATIVES, SALTS THEREOF AND METHODS OF USE
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The present invention provides amino ester compounds, salts, and pharmaceutical formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
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Paragraph 0383
(2016/08/17)
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- PYRAZOLOPYRIMIDINE INHIBITORS OF IRAK4 ACTIVITY
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The present invention relates to pyrazolopyrimidine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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Page/Page column 76
(2016/09/26)
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- PYRROLOPYRIDAZINE INHIBITORS OF IRAK4 ACTIVITY
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The present invention relates to pyrrolopyridazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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Page/Page column 44
(2016/09/26)
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- NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS
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This invention relates to novel fused quinazoline derivatives of Formula I as c-Met inhibitors, their synthesis and uses for treating c-Met mediated disorders.
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Page/Page column 45
(2014/01/17)
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- Synthesis, crystal structure and biological activity of N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide
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A new 1, 3, 4-thiadiazole compound, N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl) cyclopropanecarboxamide, was synthesized and its structure was confirmed by 1H NMR, MS and HRMS. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test showed that the synthesized compound has moderate herbicidal activity against Brassica campestris and fungicidal activities against Sclerotinia sclerotiorum(Lib.) de Bary, Rhizoctonia solanii, Fusarium oxysporum, Corynespora cassiicola, and Botrytis cinerea.
- Tong, Jian-Ying,Sun, Na-Bo,Wu, Hong-Ke,Liu, Xing-Hai
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p. 1349 - 1353
(2014/01/06)
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- Ruthenium-catalyzed asymmetric hydrogenation of 3-oxoglutaric acid derivatives: A study of unconventional solvent and substituent effects
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A series of 3-oxoglutaric acid derivatives have been hydrogenated in different solvents in the presence of [RuCl(benzene)(S)-SunPhos]Cl (SunPhos=(2,2,2′,2′-tetramethyl-[4,4′-bibenzo[d][1,3]dioxole] -5,5′-diyl)bis(diphenylphosphine)). Unlike simple β-keto acid derivatives, these advanced analogues can be readily hydrogenated in uncommon solvents such as THF, CH2Cl2, acetone, and dioxane with high enantioselectivities. Two possible catalytic cycles have been proposed to explain the different reactivities of these 1,3,5-tricarbonyl substrates in the tested solvents. The C-2 and C-4 substituents had notable but irregular influence on the reactivity and enantioselectivity of the reactions. More pronounced solvent effects were observed: the ee values increased from around 20 % in EtOH or THF to 90 % in acetone. Inversion of the product configuration was observed when the solvent was changed from EtOH to THF or acetone, and a mixed solvent system can lead to better enantioselectivity than a single solvent. Pronounced solvent effects: 3-Oxoglutaric acid derivatives have been hydrogenated in various solvents with high enantioselectivities (see scheme). Inversions of the product configuration were observed when the solvent was changed. Mixed solvent systems can give better enantioselectivities than a single solvent.
- Li, Wanfang,Tao, Xiaoming,Ma, Xin,Fan, Weizheng,Li, Xiaoming,Zhao, Mengmeng,Xie, Xiaomin,Zhang, Zhaoguo
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supporting information
p. 16531 - 16539
(2013/02/22)
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- Sc(OTf)3-catalyzed tandem [3+2] cycloaddition/nucleophilic ring-opening reaction of cyclopropane 1,1-diesters with azomethine ylides
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A new Sc(OTf)3-catalyzed tandem reaction combined with a dimerized self-[3+2] cycloaddition of azomethine ylide and a nucleophilic ring-opening of cyclopropane 1,1-diester has been developed. A series of polyfunctionalized imidazolidine derivatives were synthesized by this reaction (Yield 44-77 %). In some cases, this tandem reaction was also accompanied by a cross-[3+2] cycloaddition of cyclopropane 1,1-diester with imine.
- Fang,Hu,Ren,Wang
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p. 1479 - 1487
(2011/12/22)
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- AMINO ESTER DERIVATIVES, SAILTS THEREOF AND METHODS OF USE
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The present invention provides amino ester compounds, salts, and pharmaceutical formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
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- 1-Aminoxymethylcyclopropanecarboxylic acid as building block of β N-O turn and helix: Synthesis and conformational analysis in solution and in the solid state
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Cyclopropane side-chained β2,2-aminoxy oligopeptides were synthesized and conformationally studied. β N-O turn in solution and β N-O helix in the solid state was characterized by 1H NMR, 2D NOESY and FT-IR as well as X-ray crystallography studies. Almost no changes has been observed with the disturbance at α carbon bond angle compared with dimethyl substituted one. This study provided the opportunity to design the bioactive peptidomimetics in a more elaborate way.
- Chang, Xiao-Wei,Han, Qing-Chuan,Jiao, Zhi-Gang,Weng, Lin-Hong,Zhang, Dan-Wei
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supporting information; experimental part
p. 9733 - 9737
(2011/02/25)
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- COMPOUNDS AND METHODS OF USE
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The present invention provides novel compounds useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
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Page/Page column 99
(2010/04/30)
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- Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamides
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A series of cyclopropanecarboxamide were prepared and tested for antifungal activity in vivo. The preliminary bioassays indicated that some compounds are comparable to the commercial fungicides. To further explore the comprehensive structure-activity relationship on the basis of fungicidal activity data, comparative molecular field analysis (CoMFA) was performed, and a statistically reliable model with good predictive power (r2 = 0.8, q2 = 0.516) was achieved. Based on the CoMFA, compound 7p was designed and synthesized, which was found to display a good antifungal activity (79.38%) as 7g and 7h.
- Liu, Xing-Hai,Shi, Yan-Xia,Ma, Yi,Zhang, Chuan-Yu,Dong, Wei-Li,Pan, Li,Wang, Bao-Lei,Li, Bao-Ju,Li, Zheng-Ming
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scheme or table
p. 2782 - 2786
(2009/10/19)
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- PREPARATION OF MONTELUKAST AND ITS SALTS
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There is provided a process for the preparation of montelukast of the Formula (I).
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(2008/12/05)
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- Imidazolium salts as phase transfer catalysts for the dialkylation and cycloalkylation of active methylene compounds
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The efficient synthesis of 1,1-disubstituted derivatives and the construction of cyclopropane and cyclopentane ring systems via dialkylation and cycloalkylation reactions of active methylene compounds using imidazolium salts as phase transfer catalyst is described. The dialkylation and cycloalkylation reactions of active methylene compounds in the presence of readily available imidazolium salts (ionic liquids) as phase transfer catalysts were performed to afford the respective dialkylated or cycloalkylated products. This method is very efficient for the synthesis of 1,1-disubstituted derivatives and cyclopropane and cyclopentane ring systems in a facile manner.
- Muthusamy, Sengodagounder,Gnanaprakasam, Boopathy
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p. 635 - 638
(2007/10/03)
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- Microwave assisted phase transfer catalysis: An efficient solvent free method for the synthesis of cyclopropane derivatives
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Microwave assisted solvent free synthesis of cyclopropane derivatives 2a-e starting from active methylene compounds 1a-e and 1,2-dibromoethane under phase transfer conditions is described.
- Gumaste,Khan, Asgar J.,Bhawal,Deshmukh
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p. 420 - 422
(2007/10/03)
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- Synthesis of 5-(2-chloroalkyl)-2,2-dimethyl-1,3-dioxane-4,6-diones
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A method has been worked out to synthetize hitherto unknown 5-(2-chloroalkyl) Meldrum's acids 4 starting from easily accessible 2-chlorocarboxylic acid chlorides 1 in a two-step reaction. Reactions of dihaloethane and Meldrum's acid in the presence of potassium carbonate and the usefulness of compounds 4 are also presented.
- Toth, Gyoergy,Tamas, Tivadar,Borbely, Ildiko
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p. 3659 - 3665
(2007/10/03)
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- Process for the preparation of 1,1-cyclopropanedicarboxylic diesters
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1,1-cyclopropanedicarboxylic diesters are prepared from malonic diesters, 1,2-dihaloethane and alkali metal carbonate in the presence of a mixture of available or in situ-produced phase transfer catalyst and polyalkylene glycol or derivatives thereof which are capped at one or both ends, in particular those with ether end groups, where the molar ratio of malonic diester: 1,2-dihaloethane: alkali metal carbonate is 1:(1 to 7):(1 to 1.4).
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- Selective reactions of 1,1-cycloalkanedicarboxylic acids with SF4. a route to 1,1-bis(trifluoromethyl)cycloalkanes, 1-fluoroformyl-1-(trifluoromethyl)cycloalkanes and 1-(trifluoromethyl)-1-cycloalkanecarboxylic acids
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Six-, five-, four- and three-membered 1,1-cycloalkanedicarboxylic acid (2a-d) were synthesized by alkaline hydrolysis of the corresponding diesters (1a-d) and the reactions of the formers with SF4 were investigated. 1,1-Bis(trifluoromethyl)cycloalkanes (3a-d) were the products of the reactions conducted at 120-150°C while at 30°C 1-fluoroformyl-1-(trifluoromethyl)cycloalkanes (4a-d) were exclusively formed. The latter were isolated as pure compounds or converted in situ into 1-(trifluoromethyl)-1-cycloalkanecarboxylic acids (5a-d).
- Dmowski, Wojciech,Wolniewicz, Adam
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p. 141 - 146
(2007/10/03)
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- Preparation of esters of cyclopropane-1,1-dicarboxylic acid
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Dialkyl cyclopropane-1,1-dicarboxylates are prepared from a dialkyl malonate, a 1,2-dichloroalkane and finely divided potassium carbonate while azeotropically removing the water released by the reaction.
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- Electrosynthesis of cyclopropane derivatives by a Perkin-type reaction
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Electrolysis of active methylene compounds at a Pt cathode in MeCN in the presence of vicinal dihaloalkanes leads to cyclopropane derivatives in yields up to 90percent.In the cases of CH-acids with low pKa it is expedient to apply more active dihaloalkanes, while for CH-acids with higher pKa the desired product yields may be raised using electrogenerated bases. - Key words: CH-acids; 1,2-dihaloalkanes; cyclopropanes; electrosynthesis; electroreduction; electronegative bases; azobenzene.
- Petrosyan, V. A.,Vasil'ev, A. A.,Tatarinova, V. I.
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- Laser-Powered Decomposition of Spiroalkanes (n = 2-5)
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The laser heating of spiroalkanes (n=2-5) and of their 1,1,2,2-tetradeuterated isotopomers reveals dissimilar modes of their thermal decomposition.Spiropentane decomposes into ethene and propadiene via two competing routes: the direct cleavage and the more important cleavage via intermediary methylenecyclobutane.Spirohexane decomposes through two important concurrent pathways which are the expulsions of ethene from the three-membered ring and a more feasible expulsion of ethene from the four-membered ring.Spiroheptane and spirooctane decompose by a radical-chain mechanism and afford complex mixtures of products; upon addition of propene both compounds rearrange into two cycloalkanes wherein the larger ring of the spiroalkane is preserved and substituted with ethylidene and a vinyl group.
- Fajgar, Radek,Pola, Josef
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p. 7709 - 7717
(2007/10/02)
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- CATHODIC SYNTHESIS OF CYCLOPROPANE DERIVATIVES BY THE ELECTROLYSIS OF COMPOUNDS WITH AN ACTIVATED METHYLENE GROUP IN 1,2-DICHLOROETHANE
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The cathodic electrolysis of compounds with an activated methylene group in 1,2-dichloroethane leads to 1,1-disubstituted cyclopropanes.The current yield of these cyclopropane derivatives depends on the CH-acidity of the starting compounds and has a maximum at pKa ca.13.
- Vasil'ev, A. A.,Tatarinova, V. I.,Petrosyan, V. A.
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p. 631 - 633
(2007/10/02)
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- Preparation and Cleavage of Some Cyclopropane Derivatives
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Alkylation of active methylene compounds with 1,2-dibromoethane using anhyd.K2CO3/DMF at room temperature gives cyclopropane derivatives which undergo selective transformation by simple methods.Cyclopropanes, obtained by the condensation of α-diazoacetophenones with olefins, are cleaved to trisubstituted olefins with Grignard reagent.Hydration of the products has also been studied.
- Podder, Ranjan Kumar,Sarkar, Ranjit Kumar,Ray, Suvas C.
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p. 530 - 536
(2007/10/02)
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- Perkin-Markovnikov Type Reaction Initiated with Electrogenerated Superoxide Ion
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The cyclic condensation of α,ω-dihaloalkanes with acticvated methylene of malonic acid and acetoacetic acid esters is studied using an electrogenerated superoxide ion.Two possible mechanisms for this reaction are postulated.
- Ojima, Fumihiro,Matsue, Tomokazu,Osa, Tetsuo
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p. 2235 - 2238
(2007/10/02)
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- Co-Catalytic Effects in Phase-Transfer Catalyzed Reactions
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The phase-transfer catalyzed alkylation reaction of diethyl malonate with butyl bromide using solid potassium carbonate as base could not be accelerated above a limiting reaction rate by increasing the concentration of the onium salt catalyst.The rate limit could be exceeded by using crown ether in addition to an onium salt.Polyethylene glycols exhibit a similar effect.These results were used to improve the yields in a series of related alkylation reactions.
- Szabo, G. T.,Aranyosi, K.,Csiba, M.,Toke, L.
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p. 565 - 566
(2007/10/02)
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- A Facile Synthesis of Dialkyl Cyclopropane-1,1-dicarboxylates and Alkyl 1-Cyanocyclopropanecarboxylates by Phase-Transfer Alkylation
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The efficient syntheses of dialkyl cyclopropane-1,1-dicarboxylates and alkyl 1-cyanocyclopropanecarboxylates by alkylation of dialkyl malonates and alkyl cyanoacetates with 1,2-dihaloethanes are described.The importance of a certain amount of water under the solid-liquid phase-transfer conditions is demonstrated in the reactions.
- Heiszman, Jozsef,Bitter, Istvan,Harsanyi, Kalman,Toeke,, Laszlo
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p. 738 - 739
(2007/10/02)
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- CYCLOALKYLATION BY THE α,ω-DIBROMIDES OF COMPOUNDS CONTAINING AN ACTIVATED METHYLENE GROUP AS A METHOD FOR THE SYNTHESIS OF 1,1-DISUBSTITUTED CYCLOALKENES
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A convenient preparative method was developed for the cycloalkylation of active methylene compounds, including β-diketones, by the dibromides BrCH2(CH2)nCH2Br (n = 0,1,2) in the presence of an excess of potassium carbonate in DMSO.The reaction gives high yields for the dibromides with n = 0 and 2, whereas the formation of cyclobutanes (n=1) is complicated by O,C-alkylation.The 1-substituted 1-acylcyclopropanes undergo thermal isomerization to the corresponding dihydrofuranes.
- Zefirov, N. S.,Kuznetsova, T. S.,Kozhushkov, S. I.,Surmina, L. S.,Rashchupkina, Z. A.
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p. 474 - 480
(2007/10/02)
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