- A Protocol to Transform Sulfones into Nitrones and Aldehydes
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A simple method to transform sulfones into nitrones and therefore into the corresponding carbonyl derivatives has been developed. Some examples demonstrate that it is a new reliable and versatile reaction in the toolbox of sulfones that has great synthetic potential. NMR and computational studies were used to elucidate the mechanism.
- Rodrigo, Eduardo,Alonso, Inés,Cid, M. Belén
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supporting information
p. 5789 - 5793
(2018/09/29)
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- A Protocol to Transform Sulfones into Nitrones and Aldehydes
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A simple method to transform sulfones into nitrones and therefore into the corresponding carbonyl derivatives has been developed. Some examples demonstrate that it is a new reliable and versatile reaction in the toolbox of sulfones that has great synthetic potential. NMR and computational studies were used to elucidate the mechanism.
- Rodrigo, Eduardo,Alonso, Inés,Cid, M. Belén
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supporting information
(2018/09/27)
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- A Practical Access to Functionalized Alkyl Sulfinates
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We describe herein a three-step synthesis of aliphatic sulfinates. This cost-effective method involves the use of 2-mercaptobenzothiazole under mild conditions and exhibits good yields (up to 78% over three steps). This approach provides an access to a wi
- Tran,Flamme,Chagnes,Haddad,Phansavath,Ratovelomanana-Vidal
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p. 1622 - 1626
(2018/06/12)
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- Total synthesis of (-)-blepharocalyxin D
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The Prins cyclization strategy was successfully applied in the total synthesis of (-)-blepharocalyxin D, a cytotoxic dimeric diarylheptanoid isolated from Alpinia blepharocalyx.
- Ko, Haye Min,Lee, Dong Gil,Kim, Min Ah,Kim, Hak Joong,Park, Jaejoon,Lah, Myoung Soo,Lee, Eun
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p. 141 - 144
(2007/10/03)
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- Stereoselective synthesis of (-)-blepharocalyxin D
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The Prins cyclization strategy was successfully applied in the stereoselective synthesis of (-)-blepharocalyxin D (1), a cytotoxic dimeric diarylheptanoid isolated from Alpinia blepharocalyx.
- Ko, Haye Min,Lee, Dong Gil,Kim, Min Ah,Kim, Hak Joong,Park, Jaejoon,Lah, Myoung Soo,Lee, Eun
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p. 5797 - 5805
(2008/02/03)
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- Stereochemistry of direct olefin formation from carbonyl compounds and lithiated heterocyclic sulfones
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The conditions for the title reaction were studied for the 2-benzothiazole and 2-pyridine series and for some examples in the 2-pyrimidine series.The olefin preparations were generally observed to be more efficient for 2-BT-sulfone systems.From the data of the hundred cases studied, it can be concluded that (E)-olefins are obtained: (i) from saturated BT-sulfones and aromatic aldehydes; and (ii) from benzylic BT-sulfones and branched saturated aldehydes (isobutyraldehyde, pivalaldehyde) or α,β-ethylenic or aromatic aldehydes. (Z)-olefins arise: (i) fom propargylic BT-sulfones and saturated or aromatic aldehydes; and (ii) from allylic or benzylic Pyr-sulfones and saturated aldehydes.Possible mechanisms for this new olefination procedure were examined. - heteroaromatic sulfones, organolithium derivatives, intramolecular ipso reactions, stereochemistry, elimination, olefination.
- Baudin, J. B.,Hareau, G.,Julia, S. A.,Lorne, R.,Ruel, O.
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p. 856 - 878
(2007/10/02)
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