The present invention provides a process for the synthesis of olopatadine. Further, the invention discloses a process that results in improved yield of the desired Z isomer.
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(2014/10/03)
A simple synthesis of the novel antihistaminic drug olopatadine hydrochloride
A new alternative route for the synthesis of olopatadine is described. The present strategy involves a Lewis acid mediated ring opening of a cyclic ether to introduce 3-(dimethylamino)propylidene group as the side chain. Georg Thieme Verlag Stuttgart . New York.
Chavan, Subhash P.,Lasonkar, Pradeep B.
p. 3399 - 3403
(2014/01/06)
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