A new synthetic approach for the antiglaucoma agent, travoprost (1) has been developed in four steps from key intermediate (2). Key transformations include Horner-Wadsworth-Emmons reaction and separation of diastereomers to obtain (±) travoprost (1) and its analogs.
Mudduluru, Harikrishna,Hindupur, Rama M.,Dubey, Pramod K.,Madhavaram, Shankar,Tatini, Lakshmikumar,Subbaraju, Gottumukkala V.
experimental part
p. 234 - 241
(2012/04/18)
Storage-stable prostaglandin compositions
The use of polyethoxylated castor oils in prostaglandin compositions enhances the prostaglandin's chemical stability.
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(2008/06/13)
Storage-stable prostaglandin compositions
The use of polyethoxylated castor oils in prostaglandin compositions greatly enhances the prostaglandin's chemical stability.
-
(2008/06/13)
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