Provided is 4'-substituted nucleoside derivatives of Formula I and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.
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Page/Page column 47; 48
(2015/12/08)
7-halogenated 7-deaza-2'-deoxyinosines
The synthesis of the 7-deaza-2'-deoxyinosine derivatives 3a-c with chloro, bromo, and iodo substituents at position 7 is described. Glycosylation of the 7-halogenated 6-chloro-7-deazapurines 4a-c or of the 7- halogenated 6-chloro-7-deaza-2-(methylthio)pur
Ramzaeva, Natalya,Mittelbach, Cathrin,Seela, Frank
p. 12 - 18
(2007/10/03)
Synthesis of certain 5-substituted 2'-deoxytubercidin derivatives
The synthesis of the 7-deaza-2'-deoxy-adenine derivatives 7b-d with chloro, bromo, or methyl substituents at C(5) is described. Glycosylation of the 5-substituted 4-chloropyrrolo[2,3-d]pyrimidines 4b-d with 2-deoxy-3,5-di-O-(4-toluoyl)-α-D-erythro-pentofuranosyl chloride (3) gave the β-D-nucleosides 5b-d, exclusively. They were deblocked (→ 6b-d) and converted into the tubercidin derivatives 7b-d.
Seela,Thomas
p. 897 - 903
(2007/10/02)
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