Direct arylation of substituted pyridines with arylboronic acids catalyzed by iron(II) oxalate
The direct arylation of substituted pyridines with several arylboronic acids has been developed. This transformation could proceed readily at ambient temperature using inexpensive reagents: iron(II) oxalate as a catalyst, potassium persulfate as a co-oxidant, which can afford the arylated products in mild to good yields. The mechanism is presumed to proceed through a nucleophilic radical addition to the pyridines with in situ reoxidation.
Huang, Yibo,Guan, Dan,Wang, Liang
p. 1294 - 1298
(2015/02/05)
Iron-mediated direct arylation with arylboronic acids through an aryl radical transfer pathway
A novel iron-mediated direct C-H arylation of quinones and pyridine analogues with arylboronic acids has been developed using dichloromethane and water as solvents at ambient temperature. FeS is employed and serves as an efficient catalyst. A detailed reaction mechanism is speculated and expounded.
SYNTHESIS AND BIOLOGICAL ACTIVITIES OF NEW HMG-COA SYNTHASE INHIBITORS: 2-OXETANONES WITH A SIDE CHAIN CONTAINING BIPHENYL, TERPHENYL OR PHENYLPYRIDINE
A series of 1233A analogs containing biphenylyl, terphenylyl or phenylpyridyl groups in their side chain were synthesized and tested for the inhibitory activities against 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase and inhibition for the chol