- Reaction of 1,2-polyfluoroacylcyclohexanones with semicarbazides
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2-Polyfluoroacylcyclohexanones react with semicarbazide and thiosemicarbazide to give 2-(thio)carbamoyl-3-polyfluoroalkyl-3,3a,4,5,6,7-hexahydro-2H-indazoles, one of which was studied by X-ray diffraction.
- Pashkevich, K. I.,Sevenard, D. V.,Khomutov, O. G.,Shishkin, O. V.,Solomovich, E. V.
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- An efficient solventless synthesis of cycloalkeno-1,2,3-selenadiazoles, their antimicrobial studies, and comparison with parent semicarbazones
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[Figure not available: see fulltext.] A series of heterocyclic organoselenium compounds, cycloalkeno-1,2,3-selenadiazoles (cyclopenteno, cyclohexeno, cyclohepteno, and cycloocteno-1,2,3-selenadiazoles), was synthesized at room temperature in one step under solventless conditions from the corresponding semicarbazones. The synthesized 1,2,3-selenadiazoles and their parent semicarbazones were screened for their antimicrobial activity against various pathogenic bacteria using agar disc diffusion method. All compounds were found active against E. coli, S. aureus, S. typhi, and P. aeruginosa. Among all the tested selenadiazoles, cyclopenteno-1,2,3-selenadiazole showed excellent inhibition against highly resistant P. aeruginosa. It is observed that selenadiazoles showed higher activity compared with the respective semicarbazones.
- Jadhav, Aditi A.,Dhanwe, Vaishali P.,Joshi, Prasad G.,Khanna, Pawan K.
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- Investigating the synergism of some hydrazinecarboxamides and iodide ions as corrosion inhibitor formulations for mild steel in hydrochloric Acid: Experimental and computational studies
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Three hydrazinecarboxamides, namely, 2-cyclohexylidenehydrazinecarboxamide (SCYHEX), 2-(pentan-3-ylidene)hydrazinecarboxamide (SP3ONE) and 2-(pentan-2-ylidene)hydrazinecarboxamide (SP2ONE) were tested as inhibitors of acid corrosion of mild steel both without and with addition of iodide ions. The formulated inhibitor solutions showed excellent corrosion inhibition efficiency as they suppressed steel to the tune of 82% without KI additive, and up to 97% with KI additive. The shifts in corrosion potentials recorded from polarization measurements were anodic and ranged from 25 mV to 55 mV (without KI) relative to the uninhibited electrolyte, suggesting that the Schiff bases are mixed-type corrosion inhibitors with prominent effects on anodic dissolution of steel. The inhibitors adsorb at steel/electrolyte interface as reveled by the AC impedance measurements that showed more than 5 times increase in the charge transfer resistance and equivalence decrease in double layer capacitance of the inhibitor-containing solutions compared to the blank. Theoretical density functional theory (DFT) calculations suggested possible covalent interactions between the Schiff bases molecules and Fe with Fe—N and Fe—C bond lengths ranging from 1.87 ? to 1.96 ?. Experimentally derived synergistic parameters for Schiff bases-iodide ions interactions were generally greater than 1 and a strong H—I bond of ca. 2.3 ? length was observed in what appeared to be first time theoretical modelling of inhibitor-iodide ion synergistic interactions. DFT derived reactivity indices of protonated Schiff bases molecules correlated with the observed strengths of corrosion inhibition. Monte Carlo simulations study also confirmed the tendency of the inhibitor molecules to adsorb on mild steel surface and displace corrosive ions from the steel surface.
- Adekunle, Abolanle S.,Aniki, Nancy I.,Durodola, Solomon S.,Durosinmi, Lateefa M.,Ebenso, Eno E.,O. Wahab, Olaide,Olasunkanmi, Lukman O.
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- Cyclization of the semicarbazones to 1,3,4-oxadiazole derivatives using ceric ammonium nitrate as oxidant
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Cyclization of the semicarbazones to 1,3,4-oxadiazole using ceric ammonium nitrate as oxidant was studied. 2-Imino-1,3,4-oxadiazolines can be produced from semicarbazones, which undergo thermolysis to amides. Benzoic acid benzylidene hydrazide can also be cyclized to 2-methoxy-2-phenyl-1,3,4-oxadiazole in the presence of ceric ammonium nitrate and methanol.
- Vahedi,Lari,Bavand,Ameri
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experimental part
p. 288 - 290
(2012/08/08)
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- Basic alumina as an efficient catalyst for preparation of semicarbazones in solvent free conditions
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An efficient and simple procedure for conversion of different classes of aldehydes and ketones into the corresponding semicarbazones with semicarbazide hydrochloride using basic alumina is studied.
- Kiasat, Ali Reza,Kazemi, Foad,Mehrjardi, Mehdi Fallah
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p. 1337 - 1339
(2008/03/13)
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- Solventless rapid synthesis of oxime, semicarbazone, and phenylhydrazone derivatives from carbonyl compounds under microwave conditions
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A rapid and efficient method for the synthesis of oximes, semicarbazones, and phenylhydrazones has been reported under solventless conditions using microwave irradiation. CSIRO 2005.
- Kamakshi,Reddy, Boreddy S. R.
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p. 603 - 606
(2007/10/03)
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- Reactions of diazoalkanes with isocyanates. Synthesis of imidazolidine-2,4-diones, oxindoles, and oxazolidinones
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Thermolysis of a 5,5-dialkyl-Δ3-1,3,4-oxadiazolin-2-one in nitrobenzene containing an aryl isocyanate at 150 deg C affords a 1,3-diaryl-5,5-dialkyl imidazolidine-2,4-dione, an N-arylcarbamoyl-3,3-dialkyloxindole, and a 3-aryl-2-arylimino-5,5-dialkyl-1,3-oxazolidin-4-one.Those products arise from attack of a diazoalkane, generated in situ from the oxadiazolinone by thermal cycloreversion, on the isocyanate function.Two imidazolidine diones, three oxazolidinones, and 14 oxindoles were prepared.
- Fulton, Janet B.,Warkentin, John
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p. 1177 - 1184
(2007/10/02)
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- Reaction of Substituted Hydrazones with Thionyl Chloride and Sulfuryl Chloride
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Treatment of acetylhydrazones 2, ethoxycarbonylhydrazones 3, p-tolylsulfonylhydrazones 4 or semicarbazones 5 with thionyl chloride leads to the 1,2,3-thiadiazoles 6a-o.Sulfuryl chloride on the other hand accomplishes the transfer of chlorine without incorporating a sulfur atom.The new synthesized 1,2,3-thiadiazoles 6g-o are characterized in detail by spectroscopic methods.
- Meier, Herbert,Trickes, Georg,Laping, Elisabeth,Merkle, Ursula
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p. 183 - 192
(2007/10/02)
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