COtab: Expedient and Safe Setup for Pd-Catalyzed Carbonylation Chemistry
Bench-stable tablets (COtabs) have been developed for the rapid and safe production of carbon monoxide. The tablets can be made in less than 5 min without the use of a glovebox and only require a stock solution of an amine base to liberate a specific quantity of CO in a two-chamber system. The COtabs were tested in five different carbonylation reactions and provided similar yields compared to literature procedures. Finally, a gram-scale reaction was conducted, as well as 13C-isotope labeling of the anticancer drug, olaparib.
Collin, Hugo P.,Reis, Wallace J.,Nielsen, Dennis U.,Lindhardt, Anders T.,Valle, Marcelo S.,Freitas, Rossimiriam P.,Skrydstrup, Troels
supporting information
p. 5775 - 5778
(2019/08/26)
Correction to Palladium-Catalyzed Carbonylative Sonogashira Coupling of Aryl Bromides Using Near Stoichiometric Carbon Monoxide
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Neumann, Karoline T.,Laursen, Simon R.,Lindhardt, Anders T.,Bang-Andersen, Benny,Skrydstrup, Troels
supporting information
p. 2566 - 2566
(2015/05/27)
Palladium-catalyzed carbonylative sonogashira coupling of aryl bromides using near stoichiometric carbon monoxide
A general procedure for the palladium-catalyzed carbonylative Sonogashira coupling of aryl bromides is reported, using near stoichiometric amounts of carbon monoxide. The method allows a broad substrate scope in moderate to excellent yields. The formed alkynone motive serves as a platform for synthesis of various heterocyclic structures, including pyrimidines. Furthermore, the presented strategy allows effective 13C labeling.
Neumann, Karoline T.,Laursen, Simon R.,Lindhardt, Anders T.,Bang-Andersen, Benny,Skrydstrup, Troels
supporting information
p. 2216 - 2219
(2014/05/06)
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