- Pyrrolecarboxylic acid derivative synthesis method
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The invention discloses a pyrrolecarboxylic acid derivative synthesis method, which comprises: obtaining a group substituted formylacetone derivative by using a group substituted acetyl derivative andethyl acetate as raw materials; carrying out cyclization with diethyl aminomalonate hydrochloride to generate a pyrrolecarboxylic acid derivative ethyl ester; and carrying out a hydrolysis reaction to obtain the target product pyrrolecarboxylic acid derivative. According to the present invention, the method has characteristics of mild reaction conditions, simple purification, high yield and highproduct purity, and is suitable for process amplification and mass production.
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Paragraph 0088; 0090-0092
(2019/11/04)
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- Trimethylchlorosilane-Mediated Mild α-Chlorination of 1,3-Dicarbonyl Compounds Promoted by Phenyliodonium Diacetate
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Trimethylchlorosilane was used as chlorine source for the α-chlorination of 1,3-dicarbonyl compounds with phenyliodonium diacetate as oxidant at room temperature. The reaction allows the selective synthesis of α-monochlorinated products from different kinds of 1,3-dicarbonyl compounds in good yield. The potential possibility of this conversion for bromination has also been investigated.
- Chong, Siying,Su, Yingpeng,Wu, Lili,Zhang, Weigang,Ma, Junyan,Chen, Xiaowei,Huang, Danfeng,Wang, Ke-Hu,Hu, Yulai
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supporting information
p. 1359 - 1370
(2016/05/02)
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- Enantioselective cascade formal reductive insertion of allylic alcohols into the C(O)-C bond of 1,3-diketones: Ready access to synthetically valuable 3-alkylpentanol units
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An unprecedented cascade reaction combining dual iron-amine-catalyzed enantioselective functionalization of allylic alcohols and chemoselective acyl transfer is presented. It allows, from diketones and allylic alcohols, preparation of efficiently function
- Roudier, Mylene,Constantieux, Thierry,Quintard, Adrien,Rodriguez, Jean
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supporting information
p. 2802 - 2805
(2014/06/23)
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- New access to 1,3-diketones from aldehydes
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A simple and efficient methodology to introduce an 1,3-diketone motif from various aldehyde precursors in three steps with good overall yields is described using β-ketosulphone 7 as masked equivalent of acetone. A three-step sequence was studied leading i
- Fargeas, Valérie,Baalouch, Myriam,Metay, Estelle,Baffreau, Jer?me,Ménard, Delphine,Gosselin, Pascal,Bergé, Jean-Pascal,Barthomeuf, Chantal,Lebreton, Jacques
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p. 10359 - 10364
(2007/10/03)
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