- NOVEL EP2 RECEPTOR AGONISTS
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The compounds of formula (1), in which R1, R4, A and X have the meanings as given in the description, are novel effective EP2 agonists.
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Page/Page column 9
(2013/11/19)
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- Porphyrin compound, process for producing porphyrin compound, three-dimensional optical recording material, and three-dimensional optical recording medium
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Compounds that are suitable to be used for three-dimensional optical recording materials, etc. The compounds each have a structure that allows pi-electron conjugation to be achieved by linking a porphyrin ring and a perinaphthothioindigo ring to each other with a straight-chain atomic group. The compounds of the present invention are suitable to be used for three-dimensional optical recording materials, etc. since they have a high two-photon absorption efficiency and undergo photochromism effectively through optical absorption.
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Page/Page column 25
(2010/11/28)
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- Syntheses, characterizations, and crystal structures of β-diketiminato compounds of pentafluorophenyl group 12 derivatives, HC{[C(Me)N(C6H3-2,6-i-Pr2)]2}MC 6F5 (M = Zn, Cd)
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The reactions of H2C[C(Me)N(C6H 3-2,6-i-Pr2)]2 ((DPP)2NacNacH) and Zn(C6F5)2·2 EtCN or Cd(C 6F5)2·2 MeCN in a molar ratio of approximately 1:1 selectively gave the derivatives (DPP) 2NacNacMC6F5 (M = Zn, Cd) in excellent yields. No reaction was observed between (DPP)2NacNacH and Hg(C 6F5)2 under similar conditions. Reactions with Hg(C6F5)OCOMe yielded the products of dismutation, Hg(C6F5)2 and Hg(OCOMe)2. (DPP) 2NacNacZnC6F5 crystallises as a 1:1 adduct with THF with two independent molecules per unit cell (triclinic, P1 (no. 2)). The zinc atom is tetrahedrally surrounded by the chelating ligand, the pentafluorophenyl group and one THF molecule. A similar situation is found in the 1:1 adduct of (DPP)2NacNacCdC6F5 and DMF (monoclinic, P21/n (no. 14)), while in the donor-free compound (CDCl3 and H2O co-crystallize) the cadmium atom is nearly ideally trigonal planar co-ordinated (orthorhombic, Pbnm (no. 62)).
- Aboulkacem, Said,Tyrra, Wieland,Pantenburg, Ingo
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p. 1569 - 1574
(2008/10/08)
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- A new approach to rapid parallel development of four neurokinin antagonists. Part 2. Synthesis of ZD6021 cyano acid
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The manufacture of ZD6021 cyano acid (1) using a new project approach is described. Research Department processes were scaled up to 100 L if process safety anal robustness were not compromised; other factors were treated according to the new approach. By using this strategy, we were able to manufacture a key intermediate on sufficient scale to support delivery of 1 kg quantities of bulk drug within 6 months of the start of lab work.
- Moseley, Jonathan D.,Moss, William O.,Welham, Matthew J.,Ancell, Claire L.,Banister, John,Bowden, Sharon A.,Norton, Glenn,Young, Maureen J.
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- Facile C-mercuration of bis(diphenylphosphino)methane
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The reaction of CH2(PPh2)2 with Hg(OAc) and [Hg(Me2SO)6](O3SCF3)2 leads to {(AcOHg)n CH2-n [PPh2-(HgOAc)]2}(O3SCF3)2 (n = 1, 2), which were characterized with 199Hg and 31P NMR spectroscopy.
- Lueser, Maria,Peringer, Paul
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p. 1916 - 1917
(2008/10/08)
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