- Ruthenium(II)-Catalyzed C?H Activation/Annulation of Aromatic Hydroxamic Acid Esters with Enamides Leading to Aminal Motifs
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Hydroxamic acid ester directed C(sp2)?H activation/annulation strategy has been reported employing electron-rich enamides under Ru(II)-catalysis to access aminal frameworks. Both N-vinyl acetamide and N-vinyl formamide delivered aminals bearing
- Dana, Suman,Sureshbabu, Popuri,Giri, Chandan Kumar,Baidya, Mahiuddin
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supporting information
p. 1385 - 1389
(2021/02/26)
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- SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME
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The present invention includes substituted arylmethyl ureas and heteroarylmethyl-ureas, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.
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- Quinazolinone and isoquinolinone derivative
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The present invention relates to quinazolinone and isoquinolinone derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.
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Paragraph 0449; 0451; 0452; 0453
(2016/10/08)
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- Rhodium(III)-catalyzed C-H activation/annulation with vinyl esters as an acetylene equivalent
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The behavior of electron-rich alkenes in rhodium-catalyzed C-H activation/annulation reactions is investigated. Vinyl acetate emerges as a convenient acetylene equivalent, facilitating the synthesis of sixteen 3,4-unsubstituted isoquinolones, as well as select heteroaryl-fused pyridones. The complementary regiochemical preferences of enol ethers versus enol esters/enamides is discussed.
- Webb, Nicola J.,Marsden, Stephen P.,Raw, Steven A.
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p. 4718 - 4721
(2015/04/27)
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- Hepatitis C Virus Inhibitors
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Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
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Page/Page column 140
(2008/12/05)
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- HEPATITIS C VIRUS INHIBITORS
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Hepatitis C virus inhibitors are disclosed having the general formula:(I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds toinhibit HCV are also disclosed.
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- Palladium-catalyzed Synthesis of Isocoumarin and 1-Isoquinolinone Derivatives
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In the presence of copper(I) chloride, the palladium catalyzed oxidation of methyl 2-ethenylbenzoates and 2-ethenylbenzamides have been studied.This reaction was used to form isocoumarins and 1-isoquinolinones.
- Izumi, Taeko,Nishimoto, Yasuhiro,Kohei, Kunihiro,Kasahara, Akira
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p. 1419 - 1424
(2007/10/02)
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- The Preparation and Oxidative Dimerisation of 2-Acetyl-7-hydroxy-1,2,3,4-tetrahydroisoquinoline. A New Approach to Tetrahydroisoquinoline Synthesis
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The title compound has been prepared from 1,2,3,4-tetrahydroisoquinoline via successive nitration, acetylation, reduction and diazotisation.Earlier conflicting reports on the nitration of tetrahydroisoquinoline have been clarified.A better synthetic route
- Ajao, J. F.,Bird, C. W.
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p. 329 - 331
(2007/10/02)
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