- Efficient synthesis of tertiary acyclic amides by the Chapman rearrangement of aryl benzimidates in ionic liquids
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The Chapman rearrangement of aryl N-arylbenzimidates to tertiary acyclic amides is accelerated in ionic liquids and proceeds at lower temperatures as 120-190°C.
- Epishina, Margarita A.,Kulikov, Alexander S.,Ignat'Ev, Nikolai V.,Schulte, Michael,Makhova, Nina N.
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p. 126 - 128
(2015/04/14)
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- A simple copper-catalyzed synthesis of tertiary acyclic amides
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The N-arylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper catalytic system. The corresponding tertiary acyclic amides, which can be found in numerous biologically active compounds, have been obtained in good to excellent yields.
- Racine, Emilie,Monnier, Florian,Vors, Jean-Pierre,Taillefer, Marc
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p. 2818 - 2821
(2011/07/09)
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- Highly chemoselective metal-free reduction of tertiary amides
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This communication describes the chemoselective metal-free reduction of tertiary amides to the corresponding amines. Hantzsch ester is used as a mild reducing agent for the reduction of trifluoromethanesulfonic anhydride activated amides providing the tertiary amines with high functional group tolerance. Copyright
- Barbe, Guillaume,Charette, Andre B.
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- NUCLEAR RECEPTOR BINDING AGENTS
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The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, hot flashes or vasomotor symptoms, neurological disorders, cardiovascular disease and obesity.
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Page/Page column 135-137
(2008/06/13)
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- STUDIES ON ENAMIDES. PART 4 : PHOTOCHEMICAL INVESTIGATIONS OF N-AROYLDIPHENYLAMINES
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Photolysis of N-aroyldiphenylamines affords 9-arylacridines or phenanthridinone depending on the structure of the substrates.Additionally, carbazole and photomigrated products are also obtained.
- Datta, Indira,Das, Tapas Kumar,Ghosh, Somnath
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p. 6821 - 6830
(2007/10/02)
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- REARRANGEMENT OF NITRONES TO AMIDES USING CHLOROSULFONYL ISOCYANATE
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Reaction of chlorosulfonyl isocyanate (CSI) with nitrones 1a-n and 5a,b has been studied. α,α,N-Triaryl nitrones 1a-n react with CSI to form the N,N-diaryl arylamides 3a-n and 4i-n in good yields.In the case of α-H,α,N-diaryl nitrones 5a,b however, two compounds viz., the rearranged product 11a,b and the 1,4-dihydro tetrazines 10a,b are formed.The effect of substituents on the rearrangement has been studied.It is found that the nature of the substituents has got a profound effect on the rearrangement.We have also noted that the rearrangement is independent of the syn or anti configurations of the nitrones.
- Joseph, Sajan P.,Dhar, D. N.
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p. 5979 - 5983
(2007/10/02)
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