VARIANTS OF PHOSPHOTRIESTERASE FOR THE HYDROLYSIS AND DETOXIFICATION OF NERVE AGENTS
Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve
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Paragraph 0199
(2016/05/24)
Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template
Rapid evolution of enzymes provides unique molecular insights into the remarkable adaptability of proteins and helps to elucidate the relationship between amino acid sequence, structure, and function. We interrogated the evolution of the phosphotriesteras
Meier, Monika M.,Rajendran, Chitra,Malisi, Christoph,Fox, Nicholas G.,Xu, Chengfu,Schlee, Sandra,Barondeau, David P.,Hoecker, Birte,Sterner, Reinhard,Raushel, Frank M.
supporting information
p. 11670 - 11677
(2013/09/02)
Interaction of 0-isobutyl S-(2-N,N-dialkylamino)ethyl methylthiophosphonate with an ethylene glycol-aqueous phosphoric acid mixture