- Titanium isopropoxide promoted tandem self-cross and ring-closing metathesis approach for the synthesis of macrotetralides
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A new approach is demonstrated for the synthesis of macrotetralides through an olefin metathesis reaction using Grubbs' second-generation catalyst with titanium isopropoxide as a cocatalyst. This study demonstrates a tandem self-cross and ring-closing metathesis approach to form macrocyclic ring systems with excellent (E) selectivity. The reaction was optimized with regard to functional group, catalyst, solvent, Lewis acid, concentration, and temperature. A new approach is demonstrated for the synthesis of macrotetralides through tandem self-cross and ring-closing metathesis reactions using Grubbs' second-generation catalyst and titanium isopropoxide. Copyright
- Muthusamy, Sengodagounder,Azhagan, Datshanamoorthy
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p. 363 - 370
(2014/01/23)
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