cas 16088-19-0, 3-dimethylaminophenyl dimethylcarbamate | Articles data ｜lookchem

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16088-19-0

Articles about 16088-19-0Total 5 be found

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Synthesis and preliminary pharmacology of an internal standard for assay of neostigmine
The synthesis of the diethyl analog of neostigmine, its preliminary pharmacology, and its use as an internal standard for the GLC assay of neostigmine are described. Both the diethyl analog and neostigmine undergo thermal demethylation in the injection port. The column selected produced satisfactory resolution and short retention times for neostigmine and the diethyl analog. The diethyl analog apparently possesses acetylcholinesterase inhibiting properties, as evidenced by potentiation of the contractile response to acetylcholine on the ileum. In addition, acetylcholine levels in the brain were elevated slightly. Water solutions of the diethyl analog appeared to lose biological activity with time. The diethyl analog appears to be suitable for use as an internal standard for the GLC assay of neostigmine.
Ward Jr.,Freeman,Sowell,Kosh
p. 433 - 435
(1981)
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PROCESS FOR PREPARATION OF HIGHLY PURE 3-DIMETHYLAMINOPHENYL DIMETHYLCARBAMATE
The invention discloses a novel process for preparation of highly pure 3-dimethylaminophenyl dimethylcarbamate via formation of aryl dimethylcarbamate which can be easily obtained from diaryl carbonate and dimethylamine.
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Page/Page column 14

(2012/10/18)

Synthesis of some new o-substituted arylcarbamates and related compounds
Seven new 2-substituted-5-N',N'-dimethylaminophenyl N,N- dimethylcarbamates and three other compounds of similar structures have been synthesized aiming at obtaining potent anti-ChE agents. It has been found that the 2-substituents, regardless of their character, decrease the biological activity of the carbamates.
Barbarini, Jose E.,Rittner, Roberto,Hoeehr, Nelci F.,Suwinski, Jerzy
p. 37 - 41
(2007/10/03)

On the structure of degradation products of neostigmine bromide
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Porst,Kny
p. 325 - 328
(2007/10/02)

Kinetics of the degradation of neostigmine bromide in aqueous solution
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Porst,Kny
p. 713 - 717
(2007/10/02)

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Chemical Properties

Boiling Point: 313.6°Cat760mmHg
Flash Point:143.5°C
Density: 1.102g/cm³
Storage Temp.:2-8°C
Vapor Pressure: 0.00049mmHg at 25°C
PKA: 4.10±0.10(Predicted)
PSA: 32.78000
LogP: 1.81300

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