- COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF CANCERS
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The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.
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Paragraph 00177
(2014/07/08)
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- A mild and convenient method for the preparation of multi-isocyanates starting from primary amines
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A mild and convenient method for the synthesis and isolation of multiisocyanates, obtained from the reaction of the corresponding primary amines with di-tbutyltricarbonate (1) is described.
- Peerlings,Meijer
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p. 1021 - 1024
(2007/10/03)
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- Preparation of isocyanates from primary amines and carbon dioxide using Mitsunobu chemistry
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Primary alkylamines 1 and hindered arylamines 1 give high yields of isocyanates 5 when reacted with carbon dioxide and the Mitsunobu zwitterions 4 generated from dialkyl azodicarboxylates and Bu3P in dichloromethane at - 78°C. Use of Ph3P still gave high yields of isocyanates from reactions of primary alkylamines, but only low yields were obtained from reactions of aromatic amines. Reactions which failed to give high yields of isocyanates gave either carbamoylhydrazines 6 and/or dicarbamoylhydrazines 10 and/or triazolinones 7. The triazolinones were shown to arise from reactions of reactive aryl isocyanates with the Mitsunobu zwitterion. The carbamoylhydrazines were shown not to arise from reaction of isocyanate with reduced dialkyl azodicarboxylates, and a mechanism for their formation is proposed. Single-crystal X-ray analyses confirmed the structures of 6, 7, and 10.
- Saylik, Dilek,Horvath, Michael J.,Elmes, Patricia S.,Jackson, W. Roy,Lovel, Craig G.,Moody, Keith
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p. 3940 - 3946
(2007/10/03)
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- A Mitsunobu-based procedure for the preparation of alkyl and hindered aryl isocyanates from primary amines and carbon dioxide under mild conditions
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A Mitsunobu-based procedure for the preparation of alkyl and hindered aryl isocyanates in excellent yields from primary amines and carbon dioxide under very mild conditions is described.
- Horvath,Saylik,Elmes,Jackson,Lovel,Moody
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p. 363 - 366
(2007/10/03)
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- Neue Methode zur Synthese von Isocyanaten unter milden Bedingungen
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Keywords: Arendiyldiisocyanate; Di-tert-butyldicarbonat; 4-Dimethylaminopyridin; Isocyanate
- Knoelker, Hans-Joachim,Braxmeier, Tobias,Schlechtingen, Georg
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p. 2746 - 2749
(2007/10/03)
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- Synthesis and Reactions of the First Examples of the 1,5,2,4-Dioxadiazine Ring System: 2,4-Dialkyl-2H-1,5,2,4-dioxadiazine-3,6(4H)-diones
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The synthesis and selected reactions of 2,4-di-tert-butyl- and 2,4-bis(1,1,3,3-tetramethylbutyl)-2H-1,5,2,4-dioxadiazine-3,6(4H)-dione are described.Phosgenation of N-tert-alkylhydroxylamines gives the carbonate compounds 2 which upon further phosgenation afford the dioxadiazines 1.Acidified silica gel is required for their purification.The dioxadiazines decompose upon heating to give the corresponding nitroso compound and the isocyanate.The ring is rapidly cleaved by nucleophiles such as dimethylamine.
- Stowell, John C.,Lau, Chun M
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p. 3355 - 3357
(2007/10/02)
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