Enantioselective rhodium-catalyzed arylation of cyclic N -sulfamidate alkylketimines: A new access to chiral β-alkyl-β-aryl amino alcohols
The enantioselective rhodium-catalyzed 1,2-addition of arylboronates to cyclic N-sulfamidate alkylketimines was developed. With a rhodium/diene complex as catalyst, high enantioselectivity and broad functional group tolerance were observed. The resulting sulfamidates can easily be converted into chiral β-alkyl-β-aryl amino alcohols.