N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS
The present invention relates to a class of N-cyanopyrrolidines with activity as inhibitors of the deubiquitylating enzyme USP30, having utility in a variety of therapeutic areas, including conditions involving mitochondrial dysfunction, cancer and fibrosis: (formulae (I)(i) and (I)(ii)).
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Page/Page column 43
(2021/12/28)
PYRAZOLYL-BASED CARBOXAMIDES I AS CRAC CHANNEL INHIBITORS
The Invention relates to pyrazolyl-based carboxamide compounds of formula (l) useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to these compounds for the use in the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.
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Page/Page column 86; 94; 95
(2014/07/23)
Pyrazolyl-Based Carboxamides I
The invention relates to pyrazolyl-based carboxamide compounds useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to these compounds for the use in the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.
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(2014/07/22)
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